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Life is more complex than just having the right cellular components merely existing or even being in the right place since even in the case of extensive prebiotic chemical cheating such as using a completely dead cell with all the components in place, it is not possible generate life out of it once more by blind nature alone.<ref name="Deamer">David Deamer. 2020. Origin of life: what everyone needs to know. Oxford University Press. ISBN 0190098996. pages 87-88 "The bottom line is that ALL the essential parts of bacterial cells have been shown to work in isolation. However, no one has ever tried to put them back together. Is this even possible? Can a mixture of bacterial parts that is not alive be revived?...Are they alive? Will they grow and reproduce? After all, the ribosomes, genomes, and enzymes are all back together in one place. Most knowledgeable scientists would say, "No! They will NOT be alive!" But they can't know for sure, because no one has done the experiment. I tend share their skepticism - for a very good reason. All the components of the cell may have been put back together in a tiny membranous bag, but we have disrupted an invisible order having to do with feedback loops that regulate metabolism. In the absence of feedback controlling thousands of enzymes, it may be impossible for the cells to come back to life."</ref>
The prominent origin of life researcher [[Stanley Miller]] said the origin of life problem was more difficult than he or anyone else had imagined.<ref name="Why Abiogenesis is impossible">[https://web.archive.org/web/20170717223959/https://www.creationresearch.org/crsq/articles/36/36_4/abiogenesis.html Why Abiogenesis is impossible]</ref> Organic synthesis has been ongoing for at least 200 years and millions of molecules have been successfully synthesized, which makes it puzzling that prebiotic chemistry has not had much success in synthesizing anything close to any of the thousands of complex biomolecular machinery that make up a cell.<ref>Gilles Bruylants et al. 2011. "Prebiotic chemistry: A fuzzy field". Comptes Rendus Chimie (Proceedings of the Academy of Sciences France). 14 (4): 388–391. doi:10.1016/j.crci.2010.04.002. ISSN 1631-0748.</ref> As of 2024 numerous problems still persist for prebiotic chemists trying to solve abiogenesis.<ref name="abio 2024" />
[[Cell]]s are very optimized entities and appear to be fine tuned. Studies on raw materials used by cells such as the 20 chiral-specific [[amino acid]]s, which permeate all life on earth, are the optimal or ideal set of amino acids out of all the possible amino acid combinations.<ref>Ilardo, M., Meringer, M., Freeland, S. et al. Extraordinarily Adaptive Properties of the Genetically Encoded Amino Acids. Scientific Reports 5, 9414 (2015). https://doi.org/10.1038/srep09414</ref><ref>Doig, A.J. (2017), Frozen, but no accident – why the 20 standard amino acids were selected. FEBS J, 284: 1296-1305. https://doi.org/10.1111/febs.13982</ref>
== Current status ==
Origin of life researcher David Abel in 2024 summarizes the chemical problems that abiogenesis faces.<ref name="abio 2024">David Lynn Abel. [https://www.fortunejournals.com/articles/why-is-abiogenesis-such-a-tough-nut-to-crack.html Why is Abiogenesis Such a Tough Nut to Crack?]. Archives of Microbiology and Immunology. 8 (2024): 338-364.</ref>
Origin researcher Pier Luisi in 2018 stated "the turning point of non-life to life has never been put into one experimental set up. There are, of course, several hypotheses, and this plethora of ideas means already that we do not have a convincing one."<ref name="Luisi">Pier Luigi Luisi. 2018. The Emergence of Life: From Chemical Origins to Synthetic Biology. Cambridge University Press. ISBN 9781108735506. p. 416.</ref>
