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[[File:MillerUreyExperiment.PNG|300px|thumb|right|The setup of the Miller-Urey Experiment of 1953. It attempted to simulate primitive Earth gases (Methane, Ammonia, Hydrogen, Water Vapor), primitive oceans (Water), and lightning.]]
 
[[File:MillerUreyExperiment.PNG|300px|thumb|right|The setup of the Miller-Urey Experiment of 1953. It attempted to simulate primitive Earth gases (Methane, Ammonia, Hydrogen, Water Vapor), primitive oceans (Water), and lightning.]]
 
In 1953, Stanley Miller reported the production of biomolecules from simple gaseous starting materials using an apparatus constructed to simulate the primordial Earth's atmosphere-ocean system. Miller used what he thought was primitive gases that would be available on a primitive earth: 200 mmHg of CH<sub>4</sub>, 100 mmHg of H<sub>2</sub>, 200 mmHg of NH<sub>3</sub> and 200 ml of H<sub>2</sub>O into the equipment. In other words the ratio was 2:1:2:2 for CH<sub>4</sub>:H<sub>2</sub>:NH<sub>3</sub>:H<sub>2</sub>O. Then he subjected this mixture, under reflux, to an electric discharge simulating lightning for a week while the water was simultaneously heated for that time period.<ref name="exp setup">Parker, E. T., Cleaves, J. H., Burton, A. S., Glavin, D. P., Dworkin, J. P., Zhou, M., Bada, J. L., Fernández, F. M. [https://pmc.ncbi.nlm.nih.gov/articles/PMC4089479/ Conducting Miller-Urey Experiments]. J. Vis. Exp. (83), e51039, doi:10.3791/51039 (2014).</ref>
 
In 1953, Stanley Miller reported the production of biomolecules from simple gaseous starting materials using an apparatus constructed to simulate the primordial Earth's atmosphere-ocean system. Miller used what he thought was primitive gases that would be available on a primitive earth: 200 mmHg of CH<sub>4</sub>, 100 mmHg of H<sub>2</sub>, 200 mmHg of NH<sub>3</sub> and 200 ml of H<sub>2</sub>O into the equipment. In other words the ratio was 2:1:2:2 for CH<sub>4</sub>:H<sub>2</sub>:NH<sub>3</sub>:H<sub>2</sub>O. Then he subjected this mixture, under reflux, to an electric discharge simulating lightning for a week while the water was simultaneously heated for that time period.<ref name="exp setup">Parker, E. T., Cleaves, J. H., Burton, A. S., Glavin, D. P., Dworkin, J. P., Zhou, M., Bada, J. L., Fernández, F. M. [https://pmc.ncbi.nlm.nih.gov/articles/PMC4089479/ Conducting Miller-Urey Experiments]. J. Vis. Exp. (83), e51039, doi:10.3791/51039 (2014).</ref>
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===Results===
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In his original paper, Miller was able to identify glycine, α-alanine and β-alanine while Aspartic acid and α-aminobutyric acid  were less certain.<ref name="Miller1953">Stanley Miller. 1953. "[https://web.archive.org/web/20120317062622/http://www.abenteuer-universum.de/pdf/miller_1953.pdf Production of Amino Acids Under Possible Primitive Earth Conditions]". Science. 117 (3046): 528–9.</ref> Miller also stated "it is estimated that the total yield of amino acids was in the milligram range" which means that very little even material formed after a week of continuous running of the experiment non-stop.<ref name="Miller1953" />
 
==See also==
 
==See also==
 
*[[Origin of life]]
 
*[[Origin of life]]
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