| − | Causal association is the presence or absence of a variable (e.g. smoking) is responsible for an increase or decrease in another variable (e.g. cancer). A change in exposure leads to a change in the outcome of interest. | + | Causal association is the presence or absence of a variable (e.g. smoking) is responsible for an increase or decrease in another variable (e.g. cancer). A change in exposure leads to a change in the outcome of interest.<ref>http://www.cdc.gov/vaccines/about/terms/glossary.htm#c</ref> |