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Favoring [[neoconservative]] policies, Sasse opposed Trump's move in mid-November 2020 to pull U.S. troops from the [[Middle East]].<ref>[https://www.breitbart.com/2020-election/2020/11/18/trumps-troop-drawdowns-win-support-from-populist-gops-and-dems-criticism-from-hawks/ Trump’s Troop Drawdowns Win Support from Populist GOPs and Dems, Criticism from Hawks]</ref>

Shortly before [[Christmas]] 2025, Sasse announced that he has been diagnosed with Stage 4 pancreatic cancer and faces imminent death.