Changes

A point mutation is the most limited type of mutation, whereby a single base nucleotide is replaced with another nucleotide.  Sometimes the expression "point mutation" can also include the addition or subtraction of a single base pair.

A point [[mutation]] is the most limited type of mutation, whereby a single base [[nucleotide]] is replaced with another nucleotide.  Sometimes the expression "point mutation" can also include the addition or subtraction of a single base pair.

The sickle-cell disease has been described as a single point mutation in the beta hemoglobin gene, whereby a GAG codon is converted into GTG.  The GTG then mistakenly encodes the amino acid valine instead of glutamic acid.

The sickle-cell disease is caused by a single point mutation in the beta hemoglobin gene, whereby a GAG codon is converted into GTG.  The GTG then mistakenly encodes the amino acid valine instead of glutamic acid.