| − | '''Acetylcholine''' is a [[neurotransmitter]] found within the central and peripheral nervous systems (including the [[autonomic nervous system]]). It is one of the neurotransmitters responsible for excitatory neuronal transmission in the CNS, as well as excitatory stimulation of [[skeletal]] muscle action potentials that produce contraction. In the autonomic nervous system, it is released from post-[[ganglion]]ic [[neuron]]s of the [[parasympathetic]] system, including the [[Vagus nerve]] that innervates the [[gastrointestinal system]] and [[heart]]. | + | '''Acetylcholine''' is a [[neurotransmitter]] found within the central and peripheral nervous systems (including the [[autonomic nervous system]]). It is one of the neurotransmitters responsible for excitatory neuronal transmission in the CNS, as well as excitatory stimulation of [[skeletal]] muscle action potentials that produce contraction. In the autonomic nervous system, it is released from post-[[ganglion]]ic [[neuron]]s of the [[parasympathetic]] system, including the [[Vagus nerve]] that innervates the [[gastrointestinal system]] and [[heart]]. |
| | + | Neurons that secrete acetylcholine are referred to as "cholinergic". There are two distinct types of receptors for the neurotransmitter, named after the agonists used in their discovery: [[Nicotinic]] and [[Muscarinic]]. The former is an inotropic receptor (ion channel) and is the principle receptor located at the neuromuscular junction , while the latter is coupled to [[G proteins]] to mediate ion conductance. |