The War of the League of Cognac (1526–1530) pitted the League of Cognac (an alliance of France, England, Pope Clement VII, Venice, Florence, and elements of Milan) against the Habsburg dominions of Emperor Charles V—primarily Spain and the Holy Roman Empire. | The War of the League of Cognac (1526–1530) pitted the League of Cognac (an alliance of France, England, Pope Clement VII, Venice, Florence, and elements of Milan) against the Habsburg dominions of Emperor Charles V—primarily Spain and the Holy Roman Empire. |