Less is known about sweet and bitter substances. There seems to be no relationship between [[organic chemistry|organic]] [[functional group]]s and sweet flavor (as almost every class of compound has a member which tastes sweet), yet at the same time the chemistry is very specific. For example, saccharine is 300 times sweeter than table [[sugar]] (sucrose), however if the [[hydrogen]] bonded to the [[nitrogen]] is replaced with a [[methyl]] group, all flavor sensation disappears <ref name="Pyke" />. Likewise, bitter sensations are difficult to classify, though many [[plant]]-derived [[molecule]]s which interact with the brain such as [[caffeine]] and [[nicotine]] <ref name="Reineccius" />, as well as large molecular weight ionic salts such as [[cesium]] chloride, [[rubidium]] bromide and potassium iodide <ref name="Pyke" /> produce bitter tastes. | Less is known about sweet and bitter substances. There seems to be no relationship between [[organic chemistry|organic]] [[functional group]]s and sweet flavor (as almost every class of compound has a member which tastes sweet), yet at the same time the chemistry is very specific. For example, saccharine is 300 times sweeter than table [[sugar]] (sucrose), however if the [[hydrogen]] bonded to the [[nitrogen]] is replaced with a [[methyl]] group, all flavor sensation disappears <ref name="Pyke" />. Likewise, bitter sensations are difficult to classify, though many [[plant]]-derived [[molecule]]s which interact with the brain such as [[caffeine]] and [[nicotine]] <ref name="Reineccius" />, as well as large molecular weight ionic salts such as [[cesium]] chloride, [[rubidium]] bromide and potassium iodide <ref name="Pyke" /> produce bitter tastes. |