Susceptibility to smallpox is based to a large degree on ethnic heritage. [[Europe]]ans were plagued by it for many years and built up a resistance, whereas native [[American ]]populations were decimated when European explorers reached the Americas, almost causing extinction in many areas. | Susceptibility to smallpox is based to a large degree on ethnic heritage. [[Europe]]ans were plagued by it for many years and built up a resistance, whereas native [[American ]]populations were decimated when European explorers reached the Americas, almost causing extinction in many areas. |