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Lack of vitamin C causes scurvy because ascorbic acid provides a hydroxyl group for the hydroxylation of proline residues to from hydroxyproline in the protein collagen. These hydroxyproline residues form hydrogen bonds between chains of collagen, holding them together. Thus in the absence of vitamin C, the collagen chains fall apart, which leads to the weakened connective tissue which causes the scurvy symptoms.
Lack of vitamin C causes scurvy because ascorbic acid provides a hydroxyl group for the hydroxylation of proline residues to from hydroxyproline in the protein collagen. These hydroxyproline residues form hydrogen bonds between chains of collagen, holding them together. Thus in the absence of vitamin C, the collagen chains fall apart, which leads to the weakened connective tissue which causes the scurvy symptoms.
Many mammals are capable of generating their own vitamin C, unlike humans.<ref>[http://oilbeseeingyou.blogspot.com/2007/06/will-peak-oil-result-in-increased.html Will Peak Oil Result in an Increased Incidence of Scurvy?]</ref>
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[[category:diseases]]
[[category:diseases]]