Changes

Traditionally a few highly tested vaccines were mandatory for children to protect against deadly or severe diseases, such as [[smallpox]] and [[polio]].  In the 1990s, vaccine manufacturers began introducing and persuading states to require numerous additional vaccines for non-deadly and even sexually transmitted diseases.  About one-third of the states have philosophical exemptions entitling parents to decline the vaccines; 48 out of 50 states have religious exemptions; all states have medical exemptions, but they are hardest to obtain.<ref>http://www.nvic.org/state-site/state-exemptions.htm</ref><ref>http://www.vaccinesafety.edu/cc-exem.htm</ref>

Traditionally a few highly tested vaccines were mandatory for children to protect against deadly or severe diseases, such as [[smallpox]] and [[polio]].  In the 1990s, vaccine manufacturers began introducing and persuading states to require numerous additional vaccines for non-deadly and even sexually transmitted diseases.  About one-third of the states have philosophical exemptions entitling parents to decline the vaccines; 48 out of 50 states have religious exemptions; all states have medical exemptions, but they are hardest to obtain.<ref>http://www.nvic.org/state-site/state-exemptions.htm</ref><ref>http://www.vaccinesafety.edu/cc-exem.htm</ref>

If the body has a particular antibody for a particular disease it can identify the infection early on and the [[immune system]] can destroy it. Vaccines work by exposing the body to a form of the disease in such a way that it will not cause illness but allow antibodies to develop. This confers a level of immunity to the organism vaccinated.<ref>http://www.howstuffworks.com/immune-system7.htm How stuff works: Antibodies</ref>

If the body has a particular antibody for a particular disease it can identify the infection early on and the [[immune system]] can destroy it. Vaccines work by exposing the body to a form of the disease in such a way that it will not cause illness but allow antibodies to develop. This confers a level of immunity to the organism vaccinated.<ref>http://www.howstuffworks.com/immune-system7.htm How stuff works: Antibodies</ref>

There are four major types of vaccines and they are differentiated by what antigen is used. Live attenuated vaccines are created from the actual disease in question, however before injection the [[pathogen]] is [[attenuated]] (weakened) by growing successive generations of lines in poor nutrient conditions. It is possible for these vaccines to still cause an infection. Inactivated vaccines are created from pathogens that have been killed, usually with the use of a preservative [[formaldehyde]]. Toxoid vaccines are created by using toxins produced by the pathogen, before injection these toxins are exposed to heat and chemicals that eliminate their effect, [[antibodies]] will still be produced to these deactivated toxins. Finally, component vaccines use pieces of the pathogen in the injection. These pieces often of identifying protein segments that allow antibodies to be produced.<ref>http://www.drspock.com/article/0,1510,4866,00.html The Main Types of Vaccine </ref>

There are four major types of vaccines and they are differentiated by what antigen is used. Live attenuated vaccines are created from the actual disease in question, however before injection the [[pathogen]] is [[attenuated]] (weakened) by growing successive generations of lines in poor nutrient conditions. It is possible for these vaccines to still cause an infection. Inactivated vaccines are created from pathogens that have been killed, usually with the use of a preservative [[formaldehyde]]. Toxoid vaccines are created by using toxins produced by the pathogen, before injection these toxins are exposed to heat and chemicals that eliminate their effect, [[antibodies]] will still be produced to these deactivated toxins. Finally, component vaccines use pieces of the pathogen in the injection. These pieces often of identifying protein segments that allow antibodies to be produced.<ref>http://www.drspock.com/article/0,1510,4866,00.html The Main Types of Vaccine </ref>

Only live attenuated vaccines can still cause infection.The other three types of vaccines can cause illness, but this is an allergic response not due to the disease itself. Very rarely a serious disease known as [[eczema vaccinatum]] can emerge. Vaccines that use pieces of pathogens often use a [[carrier virus]] in the injection. Those with very weak immune systems that are exposed to such a vaccine can become infected with the carrier virus and develop [[eczema]]. A recent case of this was reported in the United States after a military man was vaccinated with small pox and his two year old son became ill. <ref> http://www.associatedcontent.com/article/183349/soldier_infects_toddler_son_with_lifethreatening.html AP article on eczema vaccinatum </ref>

Only live attenuated vaccines can still cause infection. All vaccines vaccines can cause illness, but this is commonly a hypersensitivity reaction (similar to an allergic response), not due to the disease itself. Very rarely a serious disease known as [[eczema vaccinatum]] can emerge. Vaccines that use pieces of pathogens often use a [[carrier virus]] in the injection. Those with very weak immune systems that are exposed to such a vaccine can become infected with the carrier virus and develop [[eczema]]. A recent case of this was reported in the United States after a military man was vaccinated with small pox and his two year old son became ill. <ref> http://www.associatedcontent.com/article/183349/soldier_infects_toddler_son_with_lifethreatening.html AP article on eczema vaccinatum </ref>

Since the adoption of vaccination, however, many diseases have been curbed. [[Smallpox]], a deadly disease responsible for the deaths of millions, has been mostly eliminated through vaccination. Responsible for an estimated 300 to 500 million deaths worldwide in the 20th century, effective vaccination programs of the 19th and 20th century were effective at curbing the disease, and in 1979 the World Health Organization declared smallpox to be eradicated.

A number of vaccination reactions are deemed serious enough to contraindicate further vaccinations of the same type.  These include extensive swelling and redness at the injection site, prolonged fever, [[bronchospasm]] and laryngeal [[edema]](narrowing of the airways causing difficulty in breathing), and collapse/seizures with or without unconsciousness and/or encephalitis.

 

[[Polio]], for example, killed over 3,000 people in the United States in 1952 [http://www.cdc.gov/nchs/data/vsus/VSUS_1952_2.pdf], and inflicted such noted persons as President [[Franklin Delano Roosevelt]], actor [[Alan Alda]], and musician [[Itzak Perlman]]. When doctors began using a vaccine to fight polio, it practically eradicated the disease in the developed world.

 

Other diseases that have been curbed since the invention of vaccines include [[measles]], [[mumps]], [[rubella]], and [[typhoid]].

== Influenza Vaccine ==

==Influenza Vaccine==

The flu vaccine is an example of modern vaccination.  Due to the change in [[allele]] frequency over time in the population of the influenza virus, new influenza vaccines are created each year.  According to the [http://www.cdc.gov/ CDC] <ref>"Inactivated Influenza Vaccine, What you need to know," a publication of the Center for Disease Control, 2006. Available online at: http://www.cdc.gov/nip/publications/VIS/vis-flu.pdf</ref>,  

The flu vaccine is an example of modern vaccination.  Due to the change in [[allele]] frequency over time in the population of the influenza virus, new influenza vaccines are created each year.  According to the [http://www.cdc.gov/ CDC] <ref>"Inactivated Influenza Vaccine, What you need to know," a publication of the Center for Disease Control, 2006. Available online at: http://www.cdc.gov/nip/publications/VIS/vis-flu.pdf</ref>,