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Line 28:
Line 28: − ===Deletions===+ − + − ===Insertions===+ − + − ===Single base substitutions===+ − ====Missense Mutations====+ − + − ====Nonsense Mutations====+ − + − ====Splice Site Mutations====+ − + + +
→According to Molecular Pathology: Format old post to remove headings from within post; reply.
==According to Molecular Pathology==
==According to Molecular Pathology==
There are three main classes of mutation with several subclasses.
There are three main classes of mutation with several subclasses.
*Deletions
Deletions of DNA ranging from 1 bp to megabases.
:Deletions of DNA ranging from 1 bp to megabases.
*Insertions
Insertions of DNA including duplications.
:Insertions of DNA including duplications.
*Single base substitutions
:*Missense Mutations
Replacement of one amino acid with another in the gene product.
::Replacement of one amino acid with another in the gene product.
:*Nonsense Mutations
Replacement of an amino acid codon with a stop codon.
::Replacement of an amino acid codon with a stop codon.
:*Splice Site Mutations
Create or destroy signals for exon-intron splicing
::Create or destroy signals for exon-intron splicing
Within these main classes a mutation can be consided a loss of function or gain of function. There are also Frameshifts and Dynamic Mutations. Since I did not start this article I want to know if anyone would object if I made these corrections as well as provide some background information about what exactly these mutations trully are?--[[User:Able806|Able806]] 09:07, 12 February 2008 (EST)
Within these main classes a mutation can be consided a loss of function or gain of function. There are also Frameshifts and Dynamic Mutations. Since I did not start this article I want to know if anyone would object if I made these corrections as well as provide some background information about what exactly these mutations trully are?--[[User:Able806|Able806]] 09:07, 12 February 2008 (EST)
Ok, I am assuming that this is fine and will start adding it in.--[[User:Able806|Able806]] 16:15, 15 September 2008 (EDT)
Ok, I am assuming that this is fine and will start adding it in.--[[User:Able806|Able806]] 16:15, 15 September 2008 (EDT)
:Sounds good. [[User:Philip J. Rayment|Philip J. Rayment]] 22:32, 15 September 2008 (EDT)