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Koch's postulates also have been fulfilled in animal models of human AIDS. Chimpanzees experimentally infected with HIV have developed severe immunosuppression and AIDS. In severe combined immunodeficiency (SCID) mice given a human immune system, HIV produces similar patterns of cell killing and pathogenesis as seen in people. HIV-2, a less virulent variant of HIV which causes AIDS in people, also causes an AIDS-like syndrome in baboons. More than a dozen strains of simian immunodeficiency virus (SIV), a close cousin of HIV, cause AIDS in Asian macaques. In addition, chimeric viruses known as SHIVs, which contain an SIV backbone with various HIV genes in place of the corresponding SIV genes, cause AIDS in macaques. Further strengthening the association of these viruses with AIDS, researchers have shown that SIV/SHIVs isolated from animals with AIDS cause AIDS when transmitted to uninfected animals <ref>O'Neil et al. J Infect Dis 2000;182:1051</ref><ref>Aldrovandi et al. Nature 1993;363:732</ref> <ref>Liska et al. AIDS Res Hum Retroviruses 1999;15:445</ref><ref>Locher et al. Arch Pathol Lab Med 1998;22:523</ref><ref>Hirsch et al. Virus Res 1994;32:183</ref><ref>Joag et al. J Virol 1996;70:3189</ref>.

Koch's postulates also have been fulfilled in animal models of human AIDS. Chimpanzees experimentally infected with HIV have developed severe immunosuppression and AIDS. In severe combined immunodeficiency (SCID) mice given a human immune system, HIV produces similar patterns of cell killing and pathogenesis as seen in people. HIV-2, a less virulent variant of HIV which causes AIDS in people, also causes an AIDS-like syndrome in baboons. More than a dozen strains of simian immunodeficiency virus (SIV), a close cousin of HIV, cause AIDS in Asian macaques. In addition, chimeric viruses known as SHIVs, which contain an SIV backbone with various HIV genes in place of the corresponding SIV genes, cause AIDS in macaques. Further strengthening the association of these viruses with AIDS, researchers have shown that SIV/SHIVs isolated from animals with AIDS cause AIDS when transmitted to uninfected animals <ref>O'Neil et al. J Infect Dis 2000;182:1051</ref><ref>Aldrovandi et al. Nature 1993;363:732</ref> <ref>Liska et al. AIDS Res Hum Retroviruses 1999;15:445</ref><ref>Locher et al. Arch Pathol Lab Med 1998;22:523</ref><ref>Hirsch et al. Virus Res 1994;32:183</ref><ref>Joag et al. J Virol 1996;70:3189</ref>.

==View that the cause is not HIV==

==External Links==

*[http://www.avert.org/evidence.htm AVERT] - Covers both sides of the controversy, and concludes that HIV causes AIDS

 

*[http://ourcivilisation.com/aids/cause/index.htm#Agents What Really Causes AIDS] - Mohammed Ali Al-Bayati, Ph.D., a Toxicologist with 5 letters to the editor published by ''The British Medical Journal''

*[http://ourcivilisation.com/aids/cause/index.htm#Agents What Really Causes AIDS] - Mohammed Ali Al-Bayati, Ph.D., a Toxicologist with 5 letters to the editor published by ''The British Medical Journal''

*[http://rethinkingaids.com/ Rethinking AIDS] - The connection between HIV and AIDS is invented by pharmaceutical companies in an effort to make enormous profits selling drugs (see [[HPV Vaccine]])

*[http://rethinkingaids.com/ Rethinking AIDS] - The connection between HIV and AIDS is invented by pharmaceutical companies in an effort to make enormous profits selling drugs (see [[HPV Vaccine]])

[[category:Scientific controversies]]

[[category:Scientific controversies]]

==References==

==References==

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