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Best known for the quotequotes, "Comfort the afflicted and afflict the comfortable"and "The Supreme Court follows the election returns".

Dunne wrote satirical "Mr. Dooley" columns that were nationally syndicated. In Mr. Dooley, an opinionated, first-generation, Irish-American bar owner, Dunne created a character who could criticize the nation and its most powerful people. Dunne was an anti-imperialist and bluntly addressed such topics as racismethnic rivalries, the Spanish-American war, and the imperialism of the Supreme Court.<ref>http://www.picturehistory.com/product/id/15250</ref>