Columbus did return to Spain with a number of Indian slaves, and that slave labor was used in his quest for gold. Native populations died out primarily because of exposure to new Old World diseases.<ref>http://www.history.com/content/columbusday/holiday-history History of Columbus Day</ref> | Columbus did return to Spain with a number of Indian slaves, and that slave labor was used in his quest for gold. Native populations died out primarily because of exposure to new Old World diseases.<ref>http://www.history.com/content/columbusday/holiday-history History of Columbus Day</ref> |