Spanish explorers sailed along the coast of California from the early 1500s to the mid-1700s, but no settlements were established. During the last quarter of the 18th century, the first European settlements were established in California. Father [[Junípero Serra]], a Franciscan missionary, founded the mission chain, starting with San Diego de Alcalá in 1769. The California Missions comprised a series of outposts established to spread the Christianity among the local Native Americans, with the added benefit of confirming historic Spanish claims to the area. The missions introduced European technology, livestock and crops, as well as diseases previously unknown, which decimated the tribes.<ref>http://www.californiamissions.com/cahistory/background.html</ref>
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The first quarter of the 19th century continued the slow colonization of the southern central, with a Hispanic population of about 10,000 by 1846 living mostly on cattle ranches. before 1820, Spanish influence was marked by the chain of missions reaching from San Diego to just north of today's San Francisco Bay area, and extended inland approximately 25 to 50 miles from the missions. Outside of this zone, thousands of Native Americans were continuing to lead traditional lives. The mexicoan government closed the missions.
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The highway and missions have become for many a romantic symbol of an idyllic and peaceful past. The "Mission Revival Style" was an architectural movement that drew its inspiration from this idealized view of California's past. The Spanish encouraged settlement of California with large land grants which were turned into ranchos, where cattle and sheep were raised. The Hispanic population reached about 10,000 in the 1840s, located primarily in ranches along the coast of southern California.