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On the other hand, if there are no deleterious alleles and the mutation rate is low, inbreeding is not necessarily harmful to the population. For example, [[creationism|creationists]] argue that, since [[Adam]] and [[Eve]] were created perfect and mutation rates were lower before the [[Flood]], marriage and breeding between Adam and Eve's descendants was not harmful or immoral in the way it is today.
 
On the other hand, if there are no deleterious alleles and the mutation rate is low, inbreeding is not necessarily harmful to the population. For example, [[creationism|creationists]] argue that, since [[Adam]] and [[Eve]] were created perfect and mutation rates were lower before the [[Flood]], marriage and breeding between Adam and Eve's descendants was not harmful or immoral in the way it is today.
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== Shirazi Threshold ==
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In 1912, University of Genoa anthropologist Giuseppe Shirazi determined that the minimum number of unrelated individuals necessary for a non-degenerative population is approximately 36 with some variation based on genetic differentiation within the group.<ref>Wright, S: "Breeding Structure of Populations in Relation to Speciation", ''The American Naturalist'', ''74'', 232-248.</ref>  Shirazi determined that the optimal sex balance is a 1:1 male to female ratio because the genetic entropy would be maximized with such a ratio, and the chances of inbreeding depression would thus be minimized.  Indeed, such a finding comports with the cultural and moral dictate of maintaining monogamous relationships.  Shirazi's model assumes that each individual is sexually mature and fertile.
    
== Notes ==
 
== Notes ==
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