Spain opened a mission at San Antonio in 1718 along with several small missions and military outposts, primarily to keep France from expansing from its base in Louisiana. Spain began issuing permission for American settlement, but was replaced by Mexico in 1821. | Spain opened a mission at San Antonio in 1718 along with several small missions and military outposts, primarily to keep France from expansing from its base in Louisiana. Spain began issuing permission for American settlement, but was replaced by Mexico in 1821. |