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Bedbugs have a cuticle on the outside of their body that is almost impenetrable to many insecticides used today, therefore the bugs do not pick up dried residues very well.  Bedbugs developed resistance to DDT in the 1950s, and then to its successors such as organophosphates like diazinon and malathion which were being used to clear up remaining infestations.<ref>http://www.earthfiles.com/news.php?ID=1768&category=Environment</ref> DDT resistance can possibly lead to pyrethroid resistance, as both pesticide classes act on the same target site.<ref>http://newyorkvsbedbugs.org/2010/01/21/kdr-pyrethroid-resistance-widespread-in-u-s-bed-bug-populations/</ref>
 
Bedbugs have a cuticle on the outside of their body that is almost impenetrable to many insecticides used today, therefore the bugs do not pick up dried residues very well.  Bedbugs developed resistance to DDT in the 1950s, and then to its successors such as organophosphates like diazinon and malathion which were being used to clear up remaining infestations.<ref>http://www.earthfiles.com/news.php?ID=1768&category=Environment</ref> DDT resistance can possibly lead to pyrethroid resistance, as both pesticide classes act on the same target site.<ref>http://newyorkvsbedbugs.org/2010/01/21/kdr-pyrethroid-resistance-widespread-in-u-s-bed-bug-populations/</ref>
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Bed bugs have not shown resistance to a relatively new material, ''chlorfenapyr'' (marketed as ''Phantom'').<ref>http://newyorkvsbedbugs.org/2010/08/12/the-workmanlike-chlorfenapyr</ref> which is a non-repellent, long-lasting residual killer. However, use of chlorfenapyr is only legal for licensed exterminators,<ref>http://store.parsonspestcontrol.com/msds/Phantom_Label.pdf</ref> and may require ten or more days kill the bugs, during which the bugs may still be active and females may wander and deposit viable eggs in other locations. Currently, microencapsulated materials such as contain esfenvalerate (''Onslaught'') or lamba-cyhalothrin (Demand CS) may offer the ''rapid'' reduction of susceptible populations.<ref>http://ento.psu.edu/extension/factsheets/bedbugs</ref> Also reported effective against some pyrethroid-resistant bugs were two pyrethroid-based dusts, (''Tempo Dust;'' ''Drione'') as well as diatomaceous earth.<ref>http://newyorkvsbedbugs.org/2009/05/22/finally-researchers-on-the-efficacy-of-dusts/</ref>
    
Possibly the most effective agent against bed begs, with long residual effect, is Propoxur (marketed under the registered trademark name Baygon) a carbamate pesticide with a somewhat murky regulatory history. In a test of its effectiveness against bedbugs, while some of today’s leading pesticides could not kill even half of the bugs, propoxur a well as chlorpyrifos (an organophosphate) killed them all in an hour. However, Propoxur is a neurotoxin,  toxic to humans if ingested, and [[EPA]] research has found human nervous systems could be harmed, with infants and children being in the most danger. Serious overexposure can also cause death by cardiorespiratory depression.<ref>[http://www.faqs.org/periodicals/201006/2054573271.html ''Bed Bugs: The Pesticide Dilemma'']</ref> It is therefore, like chlorpyrifos,<ref>http://www.epa.gov/oppsrrd1/op/chlorpyrifos.htm</ref> banned by the EPA for use in locations where children may be present (residential buildings and hotels). Recently, the EPA denied a request  by the state of Ohio to allow its use therein by licensed exterminators.<ref>http://bedbugger.com/2010/06/11/bed-bugs-cheer-ohios-propoxur-exemption-request-denied/</ref>  
 
Possibly the most effective agent against bed begs, with long residual effect, is Propoxur (marketed under the registered trademark name Baygon) a carbamate pesticide with a somewhat murky regulatory history. In a test of its effectiveness against bedbugs, while some of today’s leading pesticides could not kill even half of the bugs, propoxur a well as chlorpyrifos (an organophosphate) killed them all in an hour. However, Propoxur is a neurotoxin,  toxic to humans if ingested, and [[EPA]] research has found human nervous systems could be harmed, with infants and children being in the most danger. Serious overexposure can also cause death by cardiorespiratory depression.<ref>[http://www.faqs.org/periodicals/201006/2054573271.html ''Bed Bugs: The Pesticide Dilemma'']</ref> It is therefore, like chlorpyrifos,<ref>http://www.epa.gov/oppsrrd1/op/chlorpyrifos.htm</ref> banned by the EPA for use in locations where children may be present (residential buildings and hotels). Recently, the EPA denied a request  by the state of Ohio to allow its use therein by licensed exterminators.<ref>http://bedbugger.com/2010/06/11/bed-bugs-cheer-ohios-propoxur-exemption-request-denied/</ref>  
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Normally, it takes about ten years testing on rats and dogs for mutagenic effects and costs about $200 million for such a chemical to be approved by the EPA.
 
Normally, it takes about ten years testing on rats and dogs for mutagenic effects and costs about $200 million for such a chemical to be approved by the EPA.
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Bed bugs have not shown resistance to a relatively new material, ''chlorfenapyr'' (marketed as ''Phantom'').<ref>http://newyorkvsbedbugs.org/2010/08/12/the-workmanlike-chlorfenapyr</ref> which is a non-repellent, long-lasting residual killer. However, use of chlorfenapyr is only legal for licensed exterminators, and may require ten or more days kill the bugs, during which the bugs may still be active and females may wander and deposit viable eggs in other locations. Currently, microencapsulated materials such as contain esfenvalerate (''Onslaught'') or lamba-cyhalothrin (Demand CS) may offer the ''rapid'' reduction of susceptible populations.<ref>http://ento.psu.edu/extension/factsheets/bedbugs</ref> Also reported effective against some pyrethroid-resistant bugs were two pyrethroid-based dusts, (''Tempo Dust;'' ''Drione'') as well as diatomaceous earth.<ref>http://newyorkvsbedbugs.org/2009/05/22/finally-researchers-on-the-efficacy-of-dusts/</ref>
      
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