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==Recombinant hepatitis B vaccine and the risk of multiple sclerosis==

==Recombinant hepatitis B vaccine and the risk of multiple sclerosis==

A 2004 study<ref>http://www.neurology.org/cgi/content/abstract/63/5/838</ref> examined cases of 163 cases of MS and 1,604 controls. The OR of MS for vaccination within 3 years before the index date compared to no vaccination was 3.1 (95% CI 1.5, 6.3). No increased risk of MS was associated with tetanus and influenza vaccinations.  The study concluded that the findings were consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenged the idea that the relation between hepatitis B vaccination and risk of MS is well understood. However, seven separate studies of much larger sample sizes conducted between 1999 and 2001 found that any correlation between Hepatitis B vaccination and multiple sclerosis was statistically insignificant.<ref>http://www.cdc.gov/od/science/iso/concerns/archive/multiplesclerosis_and_hep_b.htm</ref>

A 2004 study<ref>http://www.neurology.org/cgi/content/abstract/63/5/838</ref> examined cases of 163 cases of MS and 1,604 controls. The OR of MS for vaccination within 3 years before the index date compared to no vaccination was 3.1 (95% CI 1.5, 6.3). No increased risk of MS was associated with tetanus and influenza vaccinations.  The study concluded that the findings were consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenged the idea that the relation between hepatitis B vaccination and risk of MS is well understood. However, seven separate studies of much larger sample sizes conducted between 1999 and 2001 found that any correlation between the hepatitis B vaccination and multiple sclerosis was statistically insignificant.<ref>http://www.cdc.gov/od/science/iso/concerns/archive/multiplesclerosis_and_hep_b.htm</ref>

==References==

==References==