Difference between revisions of "Hepatitis B vaccine"
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| − | The '''Hepatitis B vaccine''', which is required by most states of children in order to be admitted to public school, reportedly increases the risk of multiple sclerosis. Hepatitis B is not contagious in the school setting and is not required of school teachers. It is required of schoolchildren as a result of lobbying by its manufacturer, which makes a profit on every additional shot given. It is extremely lucrative for a company to pass a law that requires people to buy its product. | + | The '''Hepatitis B vaccine''', which is required by most states of children in order to be admitted to [[public school|public]] [[school]], reportedly increases the risk of [[multiple sclerosis]]. Hepatitis B is not contagious in the school setting and is not required of school teachers. It is required of schoolchildren as a result of lobbying by its manufacturer, which makes a profit on every additional shot given. It is extremely lucrative for a company to pass a law that requires people to buy its product. |
==Recombinant hepatitis B vaccine and the risk of multiple sclerosis== | ==Recombinant hepatitis B vaccine and the risk of multiple sclerosis== | ||
| − | + | A prospective study<ref>http://www.neurology.org/cgi/content/abstract/63/5/838</ref> | |
Miguel A. Hernán, MD, DrPH, Susan S. Jick, DSc, Michael J. Olek, DO and Hershel Jick, MD | Miguel A. Hernán, MD, DrPH, Susan S. Jick, DSc, Michael J. Olek, DO and Hershel Jick, MD | ||
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===Background=== | ===Background=== | ||
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A potential link between the recombinant hepatitis B vaccine and an increased risk of multiple sclerosis (MS) has been evaluated in several studies, but some of them have substantial methodologic limitations. | A potential link between the recombinant hepatitis B vaccine and an increased risk of multiple sclerosis (MS) has been evaluated in several studies, but some of them have substantial methodologic limitations. | ||
Revision as of 22:04, September 29, 2007
The Hepatitis B vaccine, which is required by most states of children in order to be admitted to public school, reportedly increases the risk of multiple sclerosis. Hepatitis B is not contagious in the school setting and is not required of school teachers. It is required of schoolchildren as a result of lobbying by its manufacturer, which makes a profit on every additional shot given. It is extremely lucrative for a company to pass a law that requires people to buy its product.
Recombinant hepatitis B vaccine and the risk of multiple sclerosis
A prospective study[1]
Miguel A. Hernán, MD, DrPH, Susan S. Jick, DSc, Michael J. Olek, DO and Hershel Jick, MD
From the Department of Epidemiology (Dr. Hernán), Harvard School of Public Health, Boston; Boston Collaborative Drug Surveillance Program (Drs. Susan S. Jick and Hershel Jick), Boston University, Lexington, MA; and Department of Neurology (Dr. Olek), College of Medicine, University of California, Irvine.
Background
A potential link between the recombinant hepatitis B vaccine and an increased risk of multiple sclerosis (MS) has been evaluated in several studies, but some of them have substantial methodologic limitations.
Methods
The authors conducted a nested case-control study within the General Practice Research Database (GPRD) in the United Kingdom.
Results
The analysis included 163 cases of MS and 1,604 controls. The OR of MS for vaccination within 3 years before the index date compared to no vaccination was 3.1 (95% CI 1.5, 6.3). No increased risk of MS was associated with tetanus and influenza vaccinations.
Conclusions
These findings are consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenge the idea that the relation between hepatitis B vaccination and risk of MS is well understood.