Difference between revisions of "Alkaline hydrolysis"

Latest revision as of 03:01, August 7, 2008

Alkaline hydrolysis is the cleavage of covalent chemical bonds by a high pH.

At high pH, RNA molecules have 2' hydroxyls that attack the 3' phosphodiester bond and degrade the RNA polymer to monoribonucleotides.

DNA lacks 2' hydroxyl groups and cannot be hydrolyzed at high pH.

Revision as of 15:21, June 5, 2007 (view source) Aschlafly (talk \| contribs) (New page: Alkaline hydrolysis is the cleavage of covalent chemical bonds by a high pH. At high pH, RNA molecules have 2' hydroxyls that attack the 3' phosphodiester bond and degrade th...)		Latest revision as of 03:01, August 7, 2008 (view source) CSGuy (talk \| contribs)
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−	Alkaline hydrolysis is the cleavage of [[covalent]] chemical bonds by a high [[pH]].	+	'''Alkaline hydrolysis''' is the cleavage of [[covalent]] chemical bonds by a high [[pH]].

	At high pH, [[RNA]] molecules have 2' hydroxyls that attack the 3' phosphodiester bond and degrade the RNA polymer to monoribonucleotides.		At high pH, [[RNA]] molecules have 2' hydroxyls that attack the 3' phosphodiester bond and degrade the RNA polymer to monoribonucleotides.