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In 2008, as a young woman, she began campaigning for her mother, who was seeking the nomination for Democratic presidential candidate in the 2008 election. After Hillary Clinton's loss to Barack Obama, the Clinton family threw their support behind the Illinois senator, and Chelsea introduced her mother as they keynote speaker at the 2008 Democratic National Convention.

In 2008, as a young woman, she began campaigning for her mother, who was seeking the nomination for Democratic presidential candidate in the 2008 election. After Hillary Clinton's loss to Barack Obama, the Clinton family threw their support behind the Illinois senator, and Chelsea introduced her mother as they keynote speaker at the 2008 Democratic National Convention.