Difference between revisions of "Hydroxychloroquine"
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== Hydroxychloroquine and coronavirus == | == Hydroxychloroquine and coronavirus == | ||
| + | Covid-19 patients taking hydroxychloroquine, alone or in combination with azithromycin, a treatment touted by President Trump, were no less likely to need mechanical ventilation and had higher deaths rates compared to those who did not take the drug, according to a study of 368 patients at US Veterans Health Administration medical centers. <ref>https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1</ref> | ||
''See also:'' [[Vladimir Zelenko's coronavirus treatment]] | ''See also:'' [[Vladimir Zelenko's coronavirus treatment]] | ||
Revision as of 22:13, April 21, 2020
Hydroxychloroqine (C18H26ClN3O), also known as hydroxychloroquine sulfate and HCQ, is a drug sold under the name Plaquenil.[1] It has been used by the physician Dr. Vladimir Zelenko as a part of successful treatment for coronavirus and was recommended for such by President Trump (see: Vladimir Zelenko's coronavirus treatment). Spefically, Dr. Zelenko used hydroxychloroqine, azithromycin (an antibiotic) and zinc as a part of his treatments to his patients.[2]
China, South Korea, and India all use hydroxychloroquine to successful combat the effects of COVID-19.
Never-Trumpers in government and hospitals block early use of this medication, and instead either withhold it from patients entirely or delay it until the end stage of the patient's life when medications are least effective.
Covid-19 patients taking hydroxychloroquine, alone or in combination with azithromycin, a treatment touted by President Trump, were no less likely to need mechanical ventilation and had higher deaths rates compared to those who did not take the drug, according to a study of 368 patients at US Veterans Health Administration medical centers. [3]
See also: Vladimir Zelenko's coronavirus treatment
The Food and Drug Administration (FDA) allows hydroxychloroquine to be used as an off-label coronavirus treatment.
According to WebMD.com: "The practice, called 'off-label" prescribing, is entirely legal and very common. More than one in five outpatient prescriptions written in the U.S. are for off-label therapies."[4] In other words, originally approved for use in humans as an anti-malarial drug, it can be prescribed by a treating physician for other uses.
Hydroxychloroquine allows zinc to penetrate the cellular wall to a larger degree.[5] Zinc is an antiviral.[6]
According to the website ResearchGate.net: "Several studies have reported that zinc has a broad-spectrum antiviral activity against a variety of viruses. Increased intracellular Zinc concentrations inhibit RNA-dependent RNA polymerases and other proteins essential for the completion of different phases of the virus life cycle. Further, zinc also helps to maintain robust immune responses by producing cytokine and by modulation of immune cell activity."[7]
Reduction in binding effect
Hydroxychlorquine reportedly "directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers":[8]
[W]e have provided clear evidence that HCQ can dissociate aPL IgG–β2GPI complexes from phospholipid bilayers. Additional studies will be needed to further define the molecular mechanism(s) for this dissociation and its possible role in modifying the APS disease process.
See also
References
- ↑ Plaquenil Uses, etc. - Drugs.com
- ↑ Marchione, Marilynn (March 23, 2020). 'Game changer'? Trump-touted malaria drugs spur hope, shortages. Washington Times. Retrieved March 28, 2020.
- ↑ https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1
- ↑ Off-Label Drug Use: What You Need to Know
- ↑ [1]
- ↑ Is a combo of chloroquine and Zinc a cure for coronavirus?
- ↑ Is a combo of chloroquine and Zinc a cure for coronavirus?
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518879/