Block, SkipCaptcha, Automoderated users, edit, rollback
6,613
edits
Changes
standardise reference formatting
Very few reliable statements about statins can be made, so the least biased way of presenting here the current state of knowledge about statins, is presenting opposing information in a dialectic, adversarial way; here are some representative examples of the published knowledge on statins:
Very few reliable statements about statins can be made, so the least biased way of presenting here the current state of knowledge about statins, is presenting opposing information in a dialectic, adversarial way; here are some representative examples of the published knowledge on statins:
Two short quotations from a reputable source Bandolier [1] related to the Oxford University (UK):
Two short quotations from a reputable source Bandolier<ref>[http://www.medicine.ox.ac.uk/bandolier/booth/cardiac/statnonL.html Non-lipid effects of statins]</ref> related to the Oxford University (UK):
"''Statins are undeniably good at altering lipid profiles and reducing morbidity and mortality associated with unfavorable lipid levels“. „Statins bring many other beneficial effects: anti-inflammatory effects, antioxidant effects, anti-thrombotic effects''"
"''Statins are undeniably good at altering lipid profiles and reducing morbidity and mortality associated with unfavorable lipid levels“. „Statins bring many other beneficial effects: anti-inflammatory effects, antioxidant effects, anti-thrombotic effects''"
(that is they prevent dangerous bursting of plaques in veins).
(that is they prevent dangerous bursting of plaques in veins).
- a summary of another article [2]:
- a summary of another article<ref>[http://www.ingentaconnect.com/content/ben/cvp;jsessionid=1i8tm4cxwox3s.alice Non-lipid effects of statins, Aylin Yildirir; Haldun Muderrisoglu, Volume 2, Number 4, October 2004 , pp. 309-318(10)]</ref>
Statins do much more than helping protecting against cholesterol-plaque build-up in arteries and from heart attacks: they reduce inflamation in veins, reduce fracture risk in osteoporosis, slow down progression of Alzheimer's disease and congestive heart failure, and may help acceptance of transplanted organs, and produce anti-inflammatory effects, antioxidant effects and antithrombotic effects.
Statins do much more than helping protecting against cholesterol-plaque build-up in arteries and from heart attacks: they reduce inflamation in veins, reduce fracture risk in osteoporosis, slow down progression of Alzheimer's disease and congestive heart failure, and may help acceptance of transplanted organs, and produce anti-inflammatory effects, antioxidant effects and antithrombotic effects.
- and conclusion from yet another reliable article [3]:
- and conclusion from yet another reliable article<ref>Chronic kidney disease (CKD) Management and General Practice, The Royal Australian College of General Practitioners), April 13, 2012</ref>:
Statins slightly improve functioning of kidneys and slows down deterioration of kidneys caused by aging.
Statins slightly improve functioning of kidneys and slows down deterioration of kidneys caused by aging.
'''
Now the opposing opinions:'''
'''
Now the opposing opinions:'''
Researchers found [4] that statins did lower the risk of heart disease, saving 271 people for every 10,000 treated. In other words, for each person whom statins saved from a heart disease, 33 men or 37 women are treated without any beneficial effect, but with a comparably-small risk of severe damages in other areas of the body: 74 develop liver dysfunction, 23 people kidney renal failure, 307 people cataracts, and 39 a muscle disease, some Rhabdomyolysis, a catastrophic decomposition of muscles, followed by kidney failure.
Researchers found <ref>Statin drugs cause liver damage, kidney failure and cataracts, says British Medical Journal, (BMJ), November 07, 2010 by: David Gutierrez, [http://www.naturalnews.com/030317_statin_drugs_liver_damage.html Naturalnews.com]</ref> that statins did lower the risk of heart disease, saving 271 people for every 10,000 treated. In other words, for each person whom statins saved from a heart disease, 33 men or 37 women are treated without any beneficial effect, but with a comparably-small risk of severe damages in other areas of the body: 74 develop liver dysfunction, 23 people kidney renal failure, 307 people cataracts, and 39 a muscle disease, some Rhabdomyolysis, a catastrophic decomposition of muscles, followed by kidney failure.
In another study (the WOSCOPS trial) 1.6% of previously healthy people had a heart attack within five years if they were not using statins, and 1.2% if they were using statins - less than one half of one percentage point of credit for statins.
In another study (the WOSCOPS trial) 1.6% of previously healthy people had a heart attack within five years if they were not using statins, and 1.2% if they were using statins - less than one half of one percentage point of credit for statins.
In another study (the CARE trial) 5.7% of people who had a previous heart attack, had another attack within five years if they were not using statins, and 4.6% if they were using statins - about one percentage point of credit for statins.
In another study (the CARE trial) 5.7% of people who had a previous heart attack, had another attack within five years if they were not using statins, and 4.6% if they were using statins - about one percentage point of credit for statins.
- and a short quotation from another article [5]:
- and a short quotation from another article <ref>Noncardiac benefits of statins found lacking, [http://www.medpagetoday.com/Cardiology/Atherosclerosis/20232 Medpagetoday.com]. By Kristina Fiore, Staff Writer, MedPage Today, Published: May 21, 2010 Reviewed by Dori F. Zaleznik, MD; Associate Clinical Professor of Medicine, Harvard Medical School, Boston and Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner</ref>:
''"Claims of unintended benefits of statins appear to be largely unsubstantiated and known risks -- including liver and renal problems and myopathy -- confirmed, British researchers concluded based on findings from a large prospective open cohort study"''
''"Claims of unintended benefits of statins appear to be largely unsubstantiated and known risks -- including liver and renal problems and myopathy -- confirmed, British researchers concluded based on findings from a large prospective open cohort study"''
==A possible resolution of the statin controversy==
==A possible resolution of the statin controversy==
The controversy is so strong, it has been lasting for so long time, and the question is so important, that Consumer Reports, a non-profit organization whose reliability has never been questioned, has stepped in and issued their report [6], which provides a balanced and cautious, yet encouraging guidance: who should use statins, what kind of statins, and how much that will cost. That paper consists from several reports, ranging from a full report, down to a simplistic summary.
The controversy is so strong, it has been lasting for so long time, and the question is so important, that Consumer Reports, a non-profit organization whose reliability has never been questioned, has stepped in and issued their report<ref>Evaluating statin drugs to treat: high cholesterol and heart disease, comparing effectiveness, safety and price. [http://www.consumerreports.org/health/best-buy-drugs/statins.htm Consumer Reports on statins]</ref>, which provides a balanced and cautious, yet encouraging guidance: who should use statins, what kind of statins, and how much that will cost. That paper consists from several reports, ranging from a full report, down to a simplistic summary.
A balanced advice: People who decide to use statins, should ask their Doctors to periodically check the kidney functions all the time the statins are used, plus up to three years after statin use discontinued, since that is how long statins’ side effects on kidneys last.
A balanced advice: People who decide to use statins, should ask their Doctors to periodically check the kidney functions all the time the statins are used, plus up to three years after statin use discontinued, since that is how long statins’ side effects on kidneys last.
==References==
==References==
<references/>
[[Category:Drugs]]
[[Category:Drugs]]