Inca
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Until it was destroyed by Spanish imperialists, the Inca civilization, which lasted from roughly 1250 to 1548 AD, was the largest empire of Pre-Columbian America. The Inca are best known for their highly advanced road system, surprisingly accurate medical knowledge, and calendar. The capital of the empire was in Cuzco, in modern Perú. The most recognizable Inca city, however, is Macchu Piccu, located high in the Peruvian Andes.