Inca
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The Inca civilization, which lasted from roughly 1250 to 1548 AD, was the largest empire of Pre-Columbian America until it was destroyed by Spanish imperialists. The Inca are best known for their highly advanced road system, surprisingly accurate medical knowledge, and calendar. The capital of the empire was in Sacsayhuamán, near Cuzco in modern Peru. The most recognizable Inca city, however, is Machu Picchu, located high in the Peruvian Andes.