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Line 15: − :in my experience people struggle with the concept of a substitution mutation increasing information. Duplication is much easier to understand. Try [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=34156 this]. If you're still not getting through, you need to make sure the subject has an appropriate understanding of the definitions of information and new information. [[User:Alexkm|Alexkm]] 09:59, 13 February 2009 (EST)+ − +
Talk:Point mutation (view source)
Revision as of 20:18, February 13, 2009
, 20:18, February 13, 2009no edit summary
Now I know this is an overly simplified example but it is possible with codons. I will give an example of a sequence as soon as I find my codons to AA matrix.--[[User:Able806|Able806]] 09:19, 13 February 2009 (EST)
Now I know this is an overly simplified example but it is possible with codons. I will give an example of a sequence as soon as I find my codons to AA matrix.--[[User:Able806|Able806]] 09:19, 13 February 2009 (EST)
:in my experience people struggle with the concept of a substitution mutation increasing information. Duplication is much easier to understand. Try [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=34156 this]. If you're still not getting through, you need to make sure the subject has an appropriate understanding of the definitions of information and new information. [[User:Alexkm|Alexkm]] 09:59, 13 February 2009 (EST)
I have no problem with understanding the idea of information addition, what I am trying to understand is why those who have problems with the idea of mutation leading to new information have issue with it. I want to know what experiments and calculations they have done to infer this. Just saying it does not make it so.--[[User:Able806|Able806]] 15:18, 13 February 2009 (EST)
::::A good, information-increasing point mutation that comes to mind is the [https://content.nejm.org/cgi/content/extract/350/20/2096 LRP5 substitution], which "[enhances] skeletal mass without causing complications of osteopetrosis". Some users may be confused by the term "High-Bone-Mass Disease". If so, please see the medical definition of [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/three/000030493.htm disease]. Some people are unwilling to open their minds to this being an instance of increased information. If that is the case, please proffer a definition of information in this context. [[User:MattL|MattL]] 10:48, 11 February 2009 (EST)
::::A good, information-increasing point mutation that comes to mind is the [https://content.nejm.org/cgi/content/extract/350/20/2096 LRP5 substitution], which "[enhances] skeletal mass without causing complications of osteopetrosis". Some users may be confused by the term "High-Bone-Mass Disease". If so, please see the medical definition of [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/three/000030493.htm disease]. Some people are unwilling to open their minds to this being an instance of increased information. If that is the case, please proffer a definition of information in this context. [[User:MattL|MattL]] 10:48, 11 February 2009 (EST)