Changes

[[Image:Marijuana vending machine.jpg|175px|thumb|right|Marijuana vending machines have been likened to [[gumball]] machines and other candy dispensors, with an emphasis on easy, recreational use instead of responsible medical use.]]

[[Image:Marijuana vending machine.jpg|175px|thumb|right|Marijuana vending machines have been likened to [[gumball]] machines and other candy dispensors, with an emphasis on easy, recreational use instead of responsible medical use.]]

'''Medical marijuana''' is [[marijuana]] used for its analgesic or otherwise therapeutic effects (see [[Glaucoma]], [[Cancer]]<ref>{{Cite journal|author=Casanova ML, Blázquez C, Martínez-Palacio J, ''et al.'' |title=Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors |journal=The Journal of Clinical Investigation |volume=111 |issue=1 |pages=43–50 |year=2003 |month=January |pmid=12511587 |pmc=151833 |doi=10.1172/JCI16116 |issn=0021-9738 |format=Free full text}}</ref><ref>{{Cite journal|author=Patsos HA, Hicks DJ, Dobson RR, ''et al.'' |title=The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2 |journal=Gut |volume=54 |issue=12 |pages=1741–50 |year=2005 |month=December |pmid=16099783 |pmc=1774787 |doi=10.1136/gut.2005.073403 |issn=0017-5749}}</ref><ref>{{Cite journal|author=Lorente M, Carracedo A, Torres S, ''et al.'' |title=Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis |journal=Glia |volume= 57|issue= 13|pages=NA |year=2009 |month=February |pmid=19229996 |doi=10.1002/glia.20856 |issn=0894-1491}}</ref><ref>{{Cite journal|author=Ramer R, Hinz B |title=Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1 |journal=Journal of the National Cancer Institute |volume=100 |issue=1 |pages=59–69 |year=2008 |month=January |pmid=18159069 |doi=10.1093/jnci/djm268 |issn=0027-8874 |url=http://jnci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=18159069 |format=Free full text}}</ref><ref>{{Cite journal|author=Powles T, te Poele R, Shamash J, ''et al.'' |title=Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway |journal=Blood |volume=105 |issue=3 |pages=1214–21 |year=2005 |month=February |pmid=15454482 |doi=10.1182/blood-2004-03-1182 |issn=0006-4971 |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=15454482 |format=Free full text}}</ref>, [[Anorexia Nervosa]]<ref>Grotenhermen, Russo. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential . New York: The Hawthorn Integrative Healing Press, 2002,. Grotenhermen, “Review of Therapeutic Effects.” Chapter 11, p. 128</ref>, [[Amyotrophic Lateral Sclerosis]]<ref>{{Cite journal|author=Carter GT, Rosen BS |title=Marijuana in the management of amyotrophic lateral sclerosis |journal=The American Journal of Hospice & Palliative Care |volume=18 |issue=4 |pages=264–70 |year=2001 |pmid=11467101 |doi=10.1177/104990910101800411 |month= July|issn=1049-9091}}</ref><ref>{{Cite journal|author=Weydt P, Hong S, Witting A, Möller T, Stella N, Kliot M |title=Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival |journal=Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders |volume=6 |issue=3 |pages=182–4 |year=2005 |month=September |pmid=16183560 |doi=10.1080/14660820510030149 |url=http://www.informaworld.com/smpp/content~db=all~content=a723777607 |issn=1466-0822}}</ref>, [[Seizures]], [[Schizophrenia]]<ref>Zuardi A.W., Crippa J.A.S., Hallak J.E.C., Moreira F.A., Guimarães F.S. Brazilian Journal of Medical and Biological Research [http://www.scielo.br/pdf/bjmbr/v39n4/6164.pdf Cannabidiol as an antipsychotic drug] (PDF) 2006. Vol. 39. Page 421-9. ISSN 0100-879X</ref>, [[tumor|Skin Tumors]]<ref>{{Cite journal|author=Casanova ML, Blázquez C, Martínez-Palacio J, ''et al.'' |title=Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors |journal=The Journal of Clinical Investigation |volume=111 |issue=1 |pages=43–50 |year=2003 |month=January |pmid=12511587 |pmc=151833 |doi=10.1172/JCI16116 |issn=0021-9738 |format=Free full text}}</ref><ref>[http://www.sciencedaily.com/releases/2007/04/070417193338.htm Science Daily 4/7/2007]</ref>, [[Gliomas]]<ref>{{Cite journal|author=Lorente M, Carracedo A, Torres S, ''et al.'' |title=Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis |journal=Glia |volume= 57|issue= 13|pages=NA |year=2009 |month=February |pmid=19229996 |doi=10.1002/glia.20856 |issn=0894-1491}}</ref><ref>{{Cite journal|author=Ramer R, Hinz B |title=Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1 |journal=Journal of the National Cancer Institute |volume=100 |issue=1 |pages=59–69 |year=2008 |month=January |pmid=18159069 |doi=10.1093/jnci/djm268 |issn=0027-8874 |url=http://jnci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=18159069 |format=Free full text}}</ref>, [[Arthritis]]<ref>{{Cite journal|author=Malfait AM, Gallily R, Sumariwalla PF, ''et al.'' |title=The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=97 |issue=17 |pages=9561–6 |year=2000 |month=August |pmid=10920191 |pmc=16904 |doi=10.1073/pnas.160105897 |issn=0027-8424 |url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10920191 |format=Free full text}}</ref>, [[Bipolar Disorder]]<ref>{{Cite journal|author=Grinspoon L, Bakalar JB |title=The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research |journal=Journal of Psychoactive Drugs |volume=30 |issue=2 |pages=171–7 |year=1998 |pmid=9692379 |url=http://www.ukcia.org/research/TheUseofCannabisasaMoodStabilizerinBipolarDisorder.html |month= April|issn=0279-1072}}</ref><ref>{{Cite journal|author=Ashton CH, Moore PB, Gallagher P, Young AH |title=Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential |journal=Journal of Psychopharmacology |volume=19 |issue=3 |pages=293–300 |year=2005 |month=May |pmid=15888515 |doi=10.1177/0269881105051541 |issn=0269-8811}}</ref>, [[Dystonia]]<ref>{{Cite journal|author=Fox SH, Kellett M, Moore AP, Crossman AR, Brotchie JM |title=Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia |journal=Movement Disorders |volume=17 |issue=1 |pages=145–9 |year=2002 |month=January |pmid=11835452 |doi=10.1002/mds.1280 |issn=0885-3185}}</ref>, [[Epilepsy]]<ref>{{cite web|url=http://www.telegraph.co.uk/science/science-news/8440303/Cannabis-could-be-used-to-treat-epilepsy.html |title=Cannabis could be used to treat epilepsy |publisher=Telegraph |date=2011-04-10 |accessdate=2011-04-20}}</ref><ref>{{Cite journal|author=Marsicano G, Goodenough S, Monory K, ''et al.'' |title=CB1 cannabinoid receptors and on-demand defense against excitotoxicity |journal=Science |volume=302 |issue=5642 |pages=84–8 |year=2003 |month=October |pmid=14526074 |doi=10.1126/science.1088208 |last12=Casanova |first12=E |last13=Schütz |first13=G |last14=Zieglgänsberger |first14=W |last15=Di Marzo |first15=V |last16=Behl |first16=C |last17=Lutz |first17=B |issn=0036-8075}}</ref><ref>{{Cite journal|author=Bacci A, Huguenard JR, Prince DA |title=Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids |journal=Nature |volume=431 |issue=7006 |pages=312–6 |year=2004 |month=September |pmid=15372034 |doi=10.1038/nature02913 |laysummary=http://www.sciencedaily.com/releases/2004/09/040916102315.htm |laysource=[[Science Daily]] |laydate=16 September 2004 |issn=0028-0836}}</ref>, [[Hepatitis C]]<ref>{{Cite journal|author=Sylvestre DL, Clements BJ, Malibu Y |title=Cannabis use improves retention and virological outcomes in patients treated for hepatitis C |journal=European Journal of Gastroenterology & Hepatology |volume=18 |issue=10 |pages=1057–63 |year=2006 |month=October |pmid=16957511 |doi=10.1097/01.meg.0000216934.22114.51 |issn=0954-691X}}</ref>, [[Depression]]<ref>{{Cite journal|author=Bambico FR, Katz N, Debonnel G, Gobbi G |title=Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex |journal=The Journal of Neuroscience |volume=27 |issue=43 |pages=11700–11 |year=2007 |month=October |pmid=17959812 |doi=10.1523/JNEUROSCI.1636-07.2007 |laysummary=http://www.foxnews.com/story/0,2933,304996,00.html |laysource=[[Fox News Channel]] |laydate=25 October 2007 |issn=0270-6474 |url=http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=17959812 |format=Free full text}}</ref><ref>{{Cite journal|author=Denson TF, Earleywine M |title=Decreased depression in marijuana users |journal=Addictive Behaviors |volume=31 |issue=4 |pages=738–42 |year=2006 |month=April |pmid=15964704 |doi=10.1016/j.addbeh.2005.05.052 |url=http://www.doctordeluca.com/Library/WOD/WPS3-MedMj/DecreasedDepressionInMjUsers05.pdf |issn=0306-4603}}</ref><ref name="Zhang_etal">{{Cite journal|author=Jiang W, Zhang Y, Xiao L, ''et al.'' |title=Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects |journal=The Journal of Clinical Investigation |volume=115 |issue=11 |pages=3104–16 |year=2005 |month=November |pmid=16224541 |pmc=1253627 |doi=10.1172/JCI25509 |issn=0021-9738 |format=Free full text}}</ref><ref>{{Cite journal|author=El-Remessy AB, Al-Shabrawey M, Khalifa Y, Tsai NT, Caldwell RB, Liou GI |title=Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes |journal=The American Journal of Pathology |volume=168 |issue=1 |pages=235–44 |year=2006 |month=January |pmid=16400026 |pmc=1592672 |doi=10.2353/ajpath.2006.050500 |issn=0002-9440 |url=http://ajp.amjpathol.org/cgi/pmidlookup?view=long&pmid=16400026 |format=Free full text}}</ref>, [[Leukemia]]<ref>{{Cite journal|author=Powles T, te Poele R, Shamash J, ''et al.'' |title=Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway |journal=Blood |volume=105 |issue=3 |pages=1214–21 |year=2005 |month=February |pmid=15454482 |doi=10.1182/blood-2004-03-1182 |issn=0006-4971 |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=15454482 |format=Free full text}}</ref>, [[Huntington's Disease]]<ref>{{cite web|url=http://www.druglibrary.org/schaffer/hemp/medical/cannabid.htm |title=Cannabidiol: The Wonder Drug of the 21st Century? |publisher=Schaffer Library of Drug Policy |date= |accessdate=10 August 2009}}{{Verify credibility|date=August 2009}}</ref>, [[Parkinson's Disease]]<ref>{{Cite journal|author=Kreitzer AC, Malenka RC |title=Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models |journal=Nature |volume=445 |issue=7128 |pages=643–7 |year=2005 |month=February |pmid=17287809 |doi=10.1038/nature05506 |laysummary=http://med.stanford.edu/news_releases/2007/february/malenka.html |laysource=[[Stanford University School of Medicine]] |laydate=7 February 2007 |issn=0028-0836}}</ref>, [[Pruritus]]<ref>{{Cite journal|author=Szepietowski JC, Szepietowski T, Reich A |title=Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study |journal=Acta Dermatovenerologica Croatica |volume=13 |issue=2 |pages=97–103 |year=2005 |pmid=16324422 |issn=1330-027X}}</ref><ref>{{Cite journal|author=Bergasa NV |title=The pruritus of cholestasis |journal=Journal of Hepatology |volume=43 |issue=6 |pages=1078–88 |year=2005 |month=December |pmid=16253381 |doi=10.1016/j.jhep.2005.09.004 |issn=0168-8278}}</ref>, [[Methicillin-Resistant Staphylococcus Aureus (MRSA)]]<ref>{{Cite journal|author=Appendino G, Gibbons S, Giana A, Pagani A, Grassi G, Stavri M, Smith E, Rahman MM |title=Antibacterial Cannabinoids from ''Cannabis sativa'': A Structure—Activity Study |journal=J Nat Prod |volume=71 |issue=8 |pages=1427–30 |year=2008|pmid=18681481 |doi=10.1021/np8002673 |url=http://pubs.acs.org/doi/pdf/10.1021/np8002673 |format=PDF |laysummary=http://www.webmd.com/news/20080904/marijuana-chemicals-may-fight-mrsa |laysource=[[WebMD]] |laydate=4 September 2008 |accessdate=6 November 2010}}</ref>, [[Sickle-Cell Disease]]<ref>{{cite web|url=http://www.ncbi.nlm.nih.gov/pubmed/16173972 |title=Cannabis use in sickle cell disease: A questionnaire study |date= |accessdate=9 June 2010}}</ref> , [[Posttraumatic Stress Disorder (PTSD)]]<ref>{{Cite journal|url=http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=123#1 |title=Science: Endocannabinoids extinguish bad memories in the brain |publisher=International Association for Cannabis as Medicine |journal=IACM-Bulletin |date=4 August 2002 |accessdate=11 August 2009}}</ref>, [[Sleep Apnea]]<ref>{{Cite journal|author=Carley DW, Paviovic S, Janelidze M, Radulovacki M |title=Functional role for cannabinoids in respiratory stability during sleep |journal=Sleep |volume=25 |issue=4 |pages=391–8 |year=2002 |month=June |pmid=12071539 |issn=0161-8105 |url=http://www.scholaruniverse.com/ncbi-linkout?id=12071539 |format=Free full text}}</ref>, and [[Artherosclerosis]]<ref>{{Cite journal|title=Cannabis may help keep arteries clear |date=16 April 2005 |doi=10.1038/nature03389 |journal=New Scientist |author=Steffens, Sabine |volume=434 |page=782 |pmid=15815632 |last1=Steffens |first1=S |last2=Veillard |first2=NR |last3=Arnaud |first3=C |last4=Pelli |first4=G |last5=Burger |first5=F |last6=Staub |first6=C |last7=Karsak |first7=M |last8=Zimmer |first8=A |last9=Frossard |first9=JL |issue=7034 |issn=0028-0836}}</ref>).

'''Medical marijuana''' is [[marijuana]] used for its analgesic or otherwise therapeutic effects (see [[Glaucoma]], [[Cancer]],<ref>{{Cite journal|author=Casanova ML, Blázquez C, Martínez-Palacio J, ''et al.'' |title=Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors |journal=The Journal of Clinical Investigation |volume=111 |issue=1 |pages=43–50 |year=2003 |month=January |pmid=12511587 |pmc=151833 |doi=10.1172/JCI16116 |issn=0021-9738 |format=Free full text}}</ref><ref>{{Cite journal|author=Patsos HA, Hicks DJ, Dobson RR, ''et al.'' |title=The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2 |journal=Gut |volume=54 |issue=12 |pages=1741–50 |year=2005 |month=December |pmid=16099783 |pmc=1774787 |doi=10.1136/gut.2005.073403 |issn=0017-5749}}</ref><ref>{{Cite journal|author=Lorente M, Carracedo A, Torres S, ''et al.'' |title=Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis |journal=Glia |volume= 57|issue= 13|pages=NA |year=2009 |month=February |pmid=19229996 |doi=10.1002/glia.20856 |issn=0894-1491}}</ref><ref>{{Cite journal|author=Ramer R, Hinz B |title=Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1 |journal=Journal of the National Cancer Institute |volume=100 |issue=1 |pages=59–69 |year=2008 |month=January |pmid=18159069 |doi=10.1093/jnci/djm268 |issn=0027-8874 |url=http://jnci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=18159069 |format=Free full text}}</ref><ref>{{Cite journal|author=Powles T, te Poele R, Shamash J, ''et al.'' |title=Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway |journal=Blood |volume=105 |issue=3 |pages=1214–21 |year=2005 |month=February |pmid=15454482 |doi=10.1182/blood-2004-03-1182 |issn=0006-4971 |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=15454482 |format=Free full text}}</ref> [[Anorexia Nervosa]],<ref>Grotenhermen, Russo. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential . New York: The Hawthorn Integrative Healing Press, 2002,. Grotenhermen, “Review of Therapeutic Effects.” Chapter 11, p. 128</ref> [[Amyotrophic Lateral Sclerosis]],<ref>{{Cite journal|author=Carter GT, Rosen BS |title=Marijuana in the management of amyotrophic lateral sclerosis |journal=The American Journal of Hospice & Palliative Care |volume=18 |issue=4 |pages=264–70 |year=2001 |pmid=11467101 |doi=10.1177/104990910101800411 |month= July|issn=1049-9091}}</ref><ref>{{Cite journal|author=Weydt P, Hong S, Witting A, Möller T, Stella N, Kliot M |title=Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival |journal=Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders |volume=6 |issue=3 |pages=182–4 |year=2005 |month=September |pmid=16183560 |doi=10.1080/14660820510030149 |url=http://www.informaworld.com/smpp/content~db=all~content=a723777607 |issn=1466-0822}}</ref> [[Seizures]], [[Schizophrenia]],<ref>Zuardi A.W., Crippa J.A.S., Hallak J.E.C., Moreira F.A., Guimarães F.S. Brazilian Journal of Medical and Biological Research [http://www.scielo.br/pdf/bjmbr/v39n4/6164.pdf Cannabidiol as an antipsychotic drug] (PDF) 2006. Vol. 39. Page 421-9. ISSN 0100-879X</ref> [[tumor|Skin Tumors]],<ref>{{Cite journal|author=Casanova ML, Blázquez C, Martínez-Palacio J, ''et al.'' |title=Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors |journal=The Journal of Clinical Investigation |volume=111 |issue=1 |pages=43–50 |year=2003 |month=January |pmid=12511587 |pmc=151833 |doi=10.1172/JCI16116 |issn=0021-9738 |format=Free full text}}</ref><ref>[http://www.sciencedaily.com/releases/2007/04/070417193338.htm Science Daily 4/7/2007]</ref> [[Gliomas]],<ref>{{Cite journal|author=Lorente M, Carracedo A, Torres S, ''et al.'' |title=Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis |journal=Glia |volume= 57|issue= 13|pages=NA |year=2009 |month=February |pmid=19229996 |doi=10.1002/glia.20856 |issn=0894-1491}}</ref><ref>{{Cite journal|author=Ramer R, Hinz B |title=Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1 |journal=Journal of the National Cancer Institute |volume=100 |issue=1 |pages=59–69 |year=2008 |month=January |pmid=18159069 |doi=10.1093/jnci/djm268 |issn=0027-8874 |url=http://jnci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=18159069 |format=Free full text}}</ref> [[Arthritis]],<ref>{{Cite journal|author=Malfait AM, Gallily R, Sumariwalla PF, ''et al.'' |title=The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=97 |issue=17 |pages=9561–6 |year=2000 |month=August |pmid=10920191 |pmc=16904 |doi=10.1073/pnas.160105897 |issn=0027-8424 |url=http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10920191 |format=Free full text}}</ref> [[Bipolar Disorder]],<ref>{{Cite journal|author=Grinspoon L, Bakalar JB |title=The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research |journal=Journal of Psychoactive Drugs |volume=30 |issue=2 |pages=171–7 |year=1998 |pmid=9692379 |url=http://www.ukcia.org/research/TheUseofCannabisasaMoodStabilizerinBipolarDisorder.html |month= April|issn=0279-1072}}</ref><ref>{{Cite journal|author=Ashton CH, Moore PB, Gallagher P, Young AH |title=Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential |journal=Journal of Psychopharmacology |volume=19 |issue=3 |pages=293–300 |year=2005 |month=May |pmid=15888515 |doi=10.1177/0269881105051541 |issn=0269-8811}}</ref> [[Dystonia]],<ref>{{Cite journal|author=Fox SH, Kellett M, Moore AP, Crossman AR, Brotchie JM |title=Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia |journal=Movement Disorders |volume=17 |issue=1 |pages=145–9 |year=2002 |month=January |pmid=11835452 |doi=10.1002/mds.1280 |issn=0885-3185}}</ref> [[Epilepsy]],<ref>{{cite web|url=http://www.telegraph.co.uk/science/science-news/8440303/Cannabis-could-be-used-to-treat-epilepsy.html |title=Cannabis could be used to treat epilepsy |publisher=Telegraph |date=2011-04-10 |accessdate=2011-04-20}}</ref><ref>{{Cite journal|author=Marsicano G, Goodenough S, Monory K, ''et al.'' |title=CB1 cannabinoid receptors and on-demand defense against excitotoxicity |journal=Science |volume=302 |issue=5642 |pages=84–8 |year=2003 |month=October |pmid=14526074 |doi=10.1126/science.1088208 |last12=Casanova |first12=E |last13=Schütz |first13=G |last14=Zieglgänsberger |first14=W |last15=Di Marzo |first15=V |last16=Behl |first16=C |last17=Lutz |first17=B |issn=0036-8075}}</ref><ref>{{Cite journal|author=Bacci A, Huguenard JR, Prince DA |title=Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids |journal=Nature |volume=431 |issue=7006 |pages=312–6 |year=2004 |month=September |pmid=15372034 |doi=10.1038/nature02913 |laysummary=http://www.sciencedaily.com/releases/2004/09/040916102315.htm |laysource=[[Science Daily]] |laydate=16 September 2004 |issn=0028-0836}}</ref> [[Hepatitis C]],<ref>{{Cite journal|author=Sylvestre DL, Clements BJ, Malibu Y |title=Cannabis use improves retention and virological outcomes in patients treated for hepatitis C |journal=European Journal of Gastroenterology & Hepatology |volume=18 |issue=10 |pages=1057–63 |year=2006 |month=October |pmid=16957511 |doi=10.1097/01.meg.0000216934.22114.51 |issn=0954-691X}}</ref> [[Depression]],<ref>{{Cite journal|author=Bambico FR, Katz N, Debonnel G, Gobbi G |title=Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex |journal=The Journal of Neuroscience |volume=27 |issue=43 |pages=11700–11 |year=2007 |month=October |pmid=17959812 |doi=10.1523/JNEUROSCI.1636-07.2007 |laysummary=http://www.foxnews.com/story/0,2933,304996,00.html |laysource=[[Fox News Channel]] |laydate=25 October 2007 |issn=0270-6474 |url=http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=17959812 |format=Free full text}}</ref><ref>{{Cite journal|author=Denson TF, Earleywine M |title=Decreased depression in marijuana users |journal=Addictive Behaviors |volume=31 |issue=4 |pages=738–42 |year=2006 |month=April |pmid=15964704 |doi=10.1016/j.addbeh.2005.05.052 |url=http://www.doctordeluca.com/Library/WOD/WPS3-MedMj/DecreasedDepressionInMjUsers05.pdf |issn=0306-4603}}</ref><ref name="Zhang_etal">{{Cite journal|author=Jiang W, Zhang Y, Xiao L, ''et al.'' |title=Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects |journal=The Journal of Clinical Investigation |volume=115 |issue=11 |pages=3104–16 |year=2005 |month=November |pmid=16224541 |pmc=1253627 |doi=10.1172/JCI25509 |issn=0021-9738 |format=Free full text}}</ref><ref>{{Cite journal|author=El-Remessy AB, Al-Shabrawey M, Khalifa Y, Tsai NT, Caldwell RB, Liou GI |title=Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes |journal=The American Journal of Pathology |volume=168 |issue=1 |pages=235–44 |year=2006 |month=January |pmid=16400026 |pmc=1592672 |doi=10.2353/ajpath.2006.050500 |issn=0002-9440 |url=http://ajp.amjpathol.org/cgi/pmidlookup?view=long&pmid=16400026 |format=Free full text}}</ref> [[Leukemia]],<ref>{{Cite journal|author=Powles T, te Poele R, Shamash J, ''et al.'' |title=Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway |journal=Blood |volume=105 |issue=3 |pages=1214–21 |year=2005 |month=February |pmid=15454482 |doi=10.1182/blood-2004-03-1182 |issn=0006-4971 |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=15454482 |format=Free full text}}</ref> [[Huntington's Disease]],<ref>{{cite web|url=http://www.druglibrary.org/schaffer/hemp/medical/cannabid.htm |title=Cannabidiol: The Wonder Drug of the 21st Century? |publisher=Schaffer Library of Drug Policy |date= |accessdate=10 August 2009}}{{Verify credibility|date=August 2009}}</ref> [[Parkinson's Disease]],<ref>{{Cite journal|author=Kreitzer AC, Malenka RC |title=Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models |journal=Nature |volume=445 |issue=7128 |pages=643–7 |year=2005 |month=February |pmid=17287809 |doi=10.1038/nature05506 |laysummary=http://med.stanford.edu/news_releases/2007/february/malenka.html |laysource=[[Stanford University School of Medicine]] |laydate=7 February 2007 |issn=0028-0836}}</ref> [[Pruritus]],<ref>{{Cite journal|author=Szepietowski JC, Szepietowski T, Reich A |title=Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study |journal=Acta Dermatovenerologica Croatica |volume=13 |issue=2 |pages=97–103 |year=2005 |pmid=16324422 |issn=1330-027X}}</ref><ref>{{Cite journal|author=Bergasa NV |title=The pruritus of cholestasis |journal=Journal of Hepatology |volume=43 |issue=6 |pages=1078–88 |year=2005 |month=December |pmid=16253381 |doi=10.1016/j.jhep.2005.09.004 |issn=0168-8278}}</ref> [[Methicillin-Resistant Staphylococcus Aureus (MRSA)]],<ref>{{Cite journal|author=Appendino G, Gibbons S, Giana A, Pagani A, Grassi G, Stavri M, Smith E, Rahman MM |title=Antibacterial Cannabinoids from ''Cannabis sativa'': A Structure—Activity Study |journal=J Nat Prod |volume=71 |issue=8 |pages=1427–30 |year=2008|pmid=18681481 |doi=10.1021/np8002673 |url=http://pubs.acs.org/doi/pdf/10.1021/np8002673 |format=PDF |laysummary=http://www.webmd.com/news/20080904/marijuana-chemicals-may-fight-mrsa |laysource=[[WebMD]] |laydate=4 September 2008 |accessdate=6 November 2010}}</ref> [[Sickle-Cell Disease]],<ref>{{cite web|url=http://www.ncbi.nlm.nih.gov/pubmed/16173972 |title=Cannabis use in sickle cell disease: A questionnaire study |date= |accessdate=9 June 2010}}</ref> [[Posttraumatic Stress Disorder (PTSD)]],<ref>{{Cite journal|url=http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=123#1 |title=Science: Endocannabinoids extinguish bad memories in the brain |publisher=International Association for Cannabis as Medicine |journal=IACM-Bulletin |date=4 August 2002 |accessdate=11 August 2009}}</ref> [[Sleep Apnea]],<ref>{{Cite journal|author=Carley DW, Paviovic S, Janelidze M, Radulovacki M |title=Functional role for cannabinoids in respiratory stability during sleep |journal=Sleep |volume=25 |issue=4 |pages=391–8 |year=2002 |month=June |pmid=12071539 |issn=0161-8105 |url=http://www.scholaruniverse.com/ncbi-linkout?id=12071539 |format=Free full text}}</ref>  and [[Artherosclerosis]]<ref>{{Cite journal|title=Cannabis may help keep arteries clear |date=16 April 2005 |doi=10.1038/nature03389 |journal=New Scientist |author=Steffens, Sabine |volume=434 |page=782 |pmid=15815632 |last1=Steffens |first1=S |last2=Veillard |first2=NR |last3=Arnaud |first3=C |last4=Pelli |first4=G |last5=Burger |first5=F |last6=Staub |first6=C |last7=Karsak |first7=M |last8=Zimmer |first8=A |last9=Frossard |first9=JL |issue=7034 |issn=0028-0836}}</ref>).

Some studies show that Cannabidiol, a chemical compound found in marijuana, inhibits cancer cell growth in lab animals<ref>Mechoulam R., Peters M., Murillo-Rodriguez E., Hanus L.O. '''Cannabidiol - recent advances'''. <i>Chemistry & Biodiversity</i>. August 2007. Vol. 4, Issue 8. Page 1678-92. pmid=17712814. doi=10.1002/cbdv.200790147</ref>. Recent studies have shown cannabidiol to be as effective as [[atypical antipsychotics]] in treating [[schizophrenia]].<ref>Zuardi A.W., Crippa J.A.S., Hallak J.E.C., Moreira F.A., Guimarães F.S. Brazilian Journal of Medical and Biological Research [http://www.scielo.br/pdf/bjmbr/v39n4/6164.pdf Cannabidiol as an antipsychotic drug] (PDF) 2006. Vol. 39. Page 421-9. ISSN 0100-879X</ref>, and [[marijuana]] is commonly viewed as a natural alternative to any otherwise synthetic pharmaceutical drugs. It has also been shown to increase brain cell growth <ref>[http://www.peak.sfu.ca/the-peak/2005-3/issue9/ne-mj.html science: Study shows marijuana increases brain cell growth ]</ref> and increase appetite, which can be useful for patients undergoing chemotherapy. Marijuana has been used to treat anorexia and has been used as an antiemetic.<ref>[http://www.cancer.gov/cancertopics/factsheet/Support/marijuana National Cancer Institute]</ref> Harvard University conducted a study on the effect of Δ-9-Tetrahydrocannabinol on certain lung cancers. The result of the test was that THC can reduce tumor size by as much as half.<ref>[http://www.sciencedaily.com/releases/2007/04/070417193338.htm Science Daily 4/7/2007]</ref> In addition to a significant reduction in tumor size, there was a reduction in lesions on the lungs by 60%, and a reduction in protein markers associated with the progression of cancer.<ref>[http://www.sciencedaily.com/releases/2007/04/070417193338.htm Science Daily 4/17/2007]</ref> This study shows that not only can THC treat the side effects of cancer treatment, but can stop the spread of cancer, repair damage caused by tumors, and even reduce the size of tumors.

Some studies show that Cannabidiol, a chemical compound found in marijuana, inhibits cancer cell growth in lab animals.<ref>Mechoulam R., Peters M., Murillo-Rodriguez E., Hanus L.O. '''Cannabidiol - recent advances'''. ''Chemistry & Biodiversity''. August 2007. Vol. 4, Issue 8. Page 1678-92. pmid=17712814. doi=10.1002/cbdv.200790147</ref> Recent studies have shown cannabidiol to be as effective as [[atypical antipsychotics]] in treating [[schizophrenia]].,<ref>Zuardi A.W., Crippa J.A.S., Hallak J.E.C., Moreira F.A., Guimarães F.S. Brazilian Journal of Medical and Biological Research [http://www.scielo.br/pdf/bjmbr/v39n4/6164.pdf Cannabidiol as an antipsychotic drug] (PDF) 2006. Vol. 39. Page 421-9. ISSN 0100-879X</ref> and [[marijuana]] is commonly viewed as a natural alternative to any otherwise synthetic pharmaceutical drugs. It has also been shown to increase brain cell growth <ref>[http://www.peak.sfu.ca/the-peak/2005-3/issue9/ne-mj.html science: Study shows marijuana increases brain cell growth ]</ref> and increase appetite, which can be useful for patients undergoing chemotherapy. Marijuana has been used to treat anorexia and has been used as an antiemetic.<ref>[http://www.cancer.gov/cancertopics/factsheet/Support/marijuana National Cancer Institute]</ref> Harvard University conducted a study on the effect of Δ-9-Tetrahydrocannabinol on certain lung cancers. The result of the test was that THC can reduce tumor size by as much as half.<ref>[http://www.sciencedaily.com/releases/2007/04/070417193338.htm Science Daily 4/7/2007]</ref> In addition to a significant reduction in tumor size, there was a reduction in lesions on the lungs by 60%, and a reduction in protein markers associated with the progression of cancer.<ref>[http://www.sciencedaily.com/releases/2007/04/070417193338.htm Science Daily 4/17/2007]</ref> This study shows that not only can THC treat the side effects of cancer treatment, but can stop the spread of cancer, repair damage caused by tumors, and even reduce the size of tumors.

In addition to the positive effect on cancer treatment symptoms and cancer itself, marijuana is used to help patients afflicted with [[amyotrophic lateral sclerosis|ALS]]<ref>[http://ajh.sagepub.com/content/18/4/264.short American Journal of Hospice and Palliative Medicine]</ref>.

In addition to the positive effect on cancer treatment symptoms and cancer itself, marijuana is used to help patients afflicted with [[amyotrophic lateral sclerosis|ALS]].<ref>[http://ajh.sagepub.com/content/18/4/264.short American Journal of Hospice and Palliative Medicine]</ref>

Marijuana is an [[antispasmodic]] and is used in the treatment of seizures <ref>[http://www.nap.edu/openbook.php?record_id=9586&page=106 National Academies Press: Marijuana and muscle spasticity]</ref>. Marijuana is also used in the treatment of migraines, arthritis<ref>[http://onlinelibrary.wiley.com/doi/10.1002/art.1780090304/abstract Online Library: Treatment of adjuvant arthritis in rats with anti-inflammatory drugs]</ref>, depression<ref>[http://www.interestingfacts.org/fact/facts-about-marijuana Interesting Facts: Facts about marijuana]</ref>, and glaucoma. However the effect of marijuana on intraocular pressure (IOC) is not as effective as those offered by other drugs on the market <ref>[http://www.nei.nih.gov/news/statements/marij.asp National Eye Institue: Glaucoma and Marijuana use]</ref>.

Marijuana is an [[antispasmodic]] and is used in the treatment of seizures.<ref>[http://www.nap.edu/openbook.php?record_id=9586&page=106 National Academies Press: Marijuana and muscle spasticity]</ref> Marijuana is also used in the treatment of migraines, arthritis,<ref>[http://onlinelibrary.wiley.com/doi/10.1002/art.1780090304/abstract Online Library: Treatment of adjuvant arthritis in rats with anti-inflammatory drugs]</ref> depression,<ref>[http://www.interestingfacts.org/fact/facts-about-marijuana Interesting Facts: Facts about marijuana]</ref> and glaucoma. However the effect of marijuana on intraocular pressure (IOC) is not as effective as those offered by other drugs on the market.<ref>[http://www.nei.nih.gov/news/statements/marij.asp National Eye Institue: Glaucoma and Marijuana use]</ref>  

Critics, however, doubt that there are any beneficial medicinal effects of marijuana that cannot be duplicated by other, less-addictive drugs.  They also charge that efforts to legalize medical marijuana are merely a pretext for general decriminalization of a common "[[gateway drug]]".

Critics, however, doubt that there are any beneficial medicinal effects of marijuana that cannot be duplicated by other, less-addictive drugs.  They also charge that efforts to legalize medical marijuana are merely a pretext for general decriminalization of a common "[[gateway drug]]".

Several states have legalized medical marijuana.  Under the [[George W. Bush|Bush]] administration, the federal government ignored such state laws, viewing them as unconstitutional interference with federal law.  [[California]]'s law was overturned by the [[Supreme Court]] in the case [[Gonzales v. Raich]] <ref>[http://www.law.cornell.edu/supct/html/03-1454.ZO.html Full text of majority opinion, ''Gonzales v. Raich'']</ref>, which said that Congress can "regulate purely local activities that are part of an economic 'class of activities' that have a substantial effect on interstate commerce."  This decision has been criticized by numerous [[conservative]]s and [[libertarian]]s as an unwarranted expansion of Federal power.  Also, current President [[Obama]] has directed Federal prosecutors to avoid prosecuting activities legal under such state laws <ref>"[http://www.justice.gov/opa/documents/medical-marijuana.pdf Memo to Justice Department attorneys]", 19 October 2009</ref>.

Several states have legalized medical marijuana.  Under the [[George W. Bush|Bush]] administration, the federal government ignored such state laws, viewing them as unconstitutional interference with federal law.  [[California]]'s law was overturned by the [[Supreme Court]] in the case [[Gonzales v. Raich]],<ref>[http://www.law.cornell.edu/supct/html/03-1454.ZO.html Full text of majority opinion, ''Gonzales v. Raich'']</ref> which said that Congress can "regulate purely local activities that are part of an economic 'class of activities' that have a substantial effect on interstate commerce."  This decision has been criticized by numerous [[conservative]]s and [[libertarian]]s as an unwarranted expansion of Federal power.  Also, current President [[Obama]] has directed Federal prosecutors to avoid prosecuting activities legal under such state laws.<ref>"[http://www.justice.gov/opa/documents/medical-marijuana.pdf Memo to Justice Department attorneys]", 19 October 2009</ref>

California currently allows patients to grow marijuana themselves for medical purposes, or to organize as "cooperatives."  Until recently, however, anyone could supply anyone with "medical" marijuana as long as the buyer had a doctor's note (which virtually anyone could obtain) and the person designated the supplier as his "primary caregiver" <ref>http://reason.com/archives/2009/10/23/medical-marijuana-muddle</ref>. Many people used this as an excuse to use marijuana recreationally.  "Medical" marijuana was even available from [[vending machine]]s,<ref>[http://www.planetc1.com/cgi-bin/n/v.cgi?c=1&id=1236007310 Marijuana Medicine Practices Are Hazy and Confusing], Planet Chiropratic dot com</ref><ref>[http://www.foxnews.com/story/0,2933,326634,00.html Medical marijuana vending machines take root in LA] Fox News</ref> similar to automated perscription dispensers at some [[pharmacies]] <ref> [http://www.scriptpro.com/products/spud/main.htm Scriptpro: Robotic Pharmaceutical Dispensing System]</ref>. Both the Drug Enformement Agency and the California Supreme Court say that such practices are illegal.  One attorney has said that he considers all sale of marijuana still illegal.  Additionally, the seriousness of having a marijuana vending machine for supposedly medical reasons is off-set by the presence of a Bob Marley poster in at least one location. Marley was a member of the Rastafari cult, which advocates the recreational use of the drug under the guise of "spiritual" reasons.

California currently allows patients to grow marijuana themselves for medical purposes, or to organize as "cooperatives."  Until recently, however, anyone could supply anyone with "medical" marijuana as long as the buyer had a doctor's note (which virtually anyone could obtain) and the person designated the supplier as his "primary caregiver".<ref>http://reason.com/archives/2009/10/23/medical-marijuana-muddle</ref>  Many people used this as an excuse to use marijuana recreationally.  "Medical" marijuana was even available from [[vending machine]]s,<ref>[http://www.planetc1.com/cgi-bin/n/v.cgi?c=1&id=1236007310 Marijuana Medicine Practices Are Hazy and Confusing], Planet Chiropratic dot com</ref><ref>[http://www.foxnews.com/story/0,2933,326634,00.html Medical marijuana vending machines take root in LA] Fox News</ref> similar to automated perscription dispensers at some [[pharmacies]].<ref>[http://www.scriptpro.com/products/spud/main.htm Scriptpro: Robotic Pharmaceutical Dispensing System]</ref>  Both the Drug Enformement Agency and the California Supreme Court say that such practices are illegal.  One attorney has said that he considers all sale of marijuana still illegal.  Additionally, the seriousness of having a marijuana vending machine for supposedly medical reasons is off-set by the presence of a Bob Marley poster in at least one location. Marley was a member of the Rastafari cult, which advocates the recreational use of the drug under the guise of "spiritual" reasons.

==References==

==References==