Due to its overall economic strength and the presence of a large population center, Cape Girardeau County is among the faster-growing counties in Missouri. A 2018 census estimate gave its current population as approximately 78,753, an increase of around 4% from 2010. | Due to its overall economic strength and the presence of a large population center, Cape Girardeau County is among the faster-growing counties in Missouri. A 2018 census estimate gave its current population as approximately 78,753, an increase of around 4% from 2010. |