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→Studies
== Studies ==
== Studies ==
On May 30, 2020, the ''Grand Rapids Herald-Review'' stated:
{{Cquote|Dr. Vladimir Zelenko serves as a Primary Care Physician in suburban New York City—the epicenter of this outbreak. “I knew that the virus would hit our area hard due to our population density—we have 32,000 people living in one square mile. So I did my own research looking at what had been done in other countries that experienced the virus before us as well as looking at treatments developed for the SARS outbreak in 2003 (another coronavirus). I developed my own protocol of a three drug cocktail: HCL, Azithromycin, and Zinc. In the last few weeks I have seen 1,450 patients with COVID symptoms. I divided my patients into two groups: high risk and low risk. The low risk patients (under age 60 and healthy) statistically get better without treatment, so I sent them home to rest and get over the virus. I gave my drug cocktail to 405 high risk patients (over age 60 or with underlying health problems) whose conditions were most severe. The accepted rate of COVID mortality at that time for high risk patients was 5%, so if I had just relied on ventilators I could have expected to see 20 of my patients die. But using these three drugs I only lost two patients, one of which was very old and had been chronically ill. This was a significant order of magnitude better than expected outcomes.”
Dr. Zelenko explains the rationale behind his treatment program. “The zinc is what kills the virus and zinc occurs naturally in the body but has a hard time penetrating the cell where the virus lives. What the hydroxychloroquine does is open a channel into the cell so the zinc can enter and stop the virus from replicating. Adding an extra dose of zinc to the cocktail has been shown to improve outcomes by about 25%. Meanwhile, the azithromycin stands guard to combat any secondary bacterial infection that may crash the party and cause pneumonia.”
After seeing the effectiveness of his treatment regimen, Dr. Zelenko stated, “I realized what I had, and I felt like a front line soldier who had stumbled across some very important intelligence—some valuable information that needed to be communicated to the 5-star general because that information could be used to win the war.”
Within a few weeks, Dr. Zelenko had published video reports of his findings and was in touch not only with the US Coronavirus Taskforce, but with over a dozen governments around the world from Russia, to South Africa, to Peru. Four weeks ago the government of Brazil began implementing Dr. Zelenko’s protocol, and he explains their results: “One week ago the Brazilians published a study revealing a 95% reduction in deaths after this drug cocktail was introduced for use in their government hospitals.”<ref>[https://www.grandrapidsmn.com/opinion/doctors-discover-effective-life-saving-treatment-for-covid-19/article_3619c254-a1d4-11ea-a886-43929db0aeb5.html Doctors discover effective, life-saving treatment for Covid-19] By Rev. Mark Peske Our Redeemer Lutheran Church, Grand Rapids Herald-Review, May 30, 2020</ref>}}
"Early Hydroxychloroquine Is Associated with an Increase of Survival," reports a study in Spain on May 5, 2020:<ref>https://www.preprints.org/manuscript/202005.0057/v1 (emphasis added).</ref>
"Early Hydroxychloroquine Is Associated with an Increase of Survival," reports a study in Spain on May 5, 2020:<ref>https://www.preprints.org/manuscript/202005.0057/v1 (emphasis added).</ref>
:Methods: We enrolled all 18-85 years old inpatients from Central Defense Hospital “Gómez Ulla”, Madrid, Spain, who were hospitalised for COVID-19 and had a definitive outcome (dead or discharged). We used a statistical survival analysis to detect treatment differences associated with in-hospital death. Results: We analysed first 220 medical records. 166 patients met the inclusion criteria. 48,8 % of patients not treated with HCQ died, 22% of those treated with hydroxychloroquine (p=0,002). According to clinical picture at admission, hydroxychloroquine increased the mean cumulative survival in all groups from 1,4 to 1,8 times. '''''This difference was statistically significant in the mild group.'''''
:Methods: We enrolled all 18-85 years old inpatients from Central Defense Hospital “Gómez Ulla”, Madrid, Spain, who were hospitalised for COVID-19 and had a definitive outcome (dead or discharged). We used a statistical survival analysis to detect treatment differences associated with in-hospital death. Results: We analysed first 220 medical records. 166 patients met the inclusion criteria. 48,8 % of patients not treated with HCQ died, 22% of those treated with hydroxychloroquine (p=0,002). According to clinical picture at admission, hydroxychloroquine increased the mean cumulative survival in all groups from 1,4 to 1,8 times. '''''This difference was statistically significant in the mild group.'''''
:Conclusions: in a cohort of 166 patients from 18 to 85 years hospitalised with COVID-19, hydroxychloroquine treatment with 800mg added loading dose increased survival when patients were admitted in early stages of the disease. '''''There was a non-statistically significant trend towards survival in all groups, which will have to be clarified in subsequent studies.'''''
:Conclusions: in a cohort of 166 patients from 18 to 85 years hospitalised with COVID-19, hydroxychloroquine treatment with 800mg added loading dose increased survival when patients were admitted in early stages of the disease. '''''There was a non-statistically significant trend towards survival in all groups, which will have to be clarified in subsequent studies.'''''
== CDC ==
== CDC ==