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This is a new page called Zinc Ionophores
Zinc ionophores are compounds that bind on zinc, and transport the extracellular Zn2+ ions across the cell membrane, and are researched for their anticancer and antiviral tendencies.<ref>https://pubmed.ncbi.nlm.nih.gov/19859983/</ref><ref>https://biomedgrid.com/fulltext/volume2/review-on-the-role-of-zn2+-ions-in-viral-pathogenesis-and-the-effect-of-zn2+-ions-for-host-cell-virus-growth-inhibition.000566.php</ref> Examples of Zinc Ionophores are [[Hinokitiol]] (HK) and [http://Pyrithione Pyrithione] (PT) and have been found to inhibit human [http://mengovirus mengovirus], [http://rhinovirus rhinovirus], and [http://coxsackievirus coxsackievirus] multiplication effectively.<ref>https://jvi.asm.org/content/83/1/58</ref> [http://Chloroquine Chloroquine] has also been identified as a Zinc Ionophore that portrays its anticancer capability, and it has been considered as a potential anticancer agent.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/</ref>
== Antiviral Activity ==
Zinc Ionophores, Hinokitiol, and Pyrithione are useful in the inhibition of Picornavirus replication through the interference with the viral polyprotein proper processing.<ref>https://pubmed.ncbi.nlm.nih.gov/18922875/</ref> Hinokitiol and Pyrithione also result in a swift importation of extracellular Zn2+ ions into the cells, which increases the inhibition against Picornavirus infection.<ref>https://jvi.asm.org/content/83/1/58</ref>
== Anticancer Activity ==
The ability to bind on Zinc ions allows Zinc ionophores to cause apoptosis within cancer cells.<ref>https://pubmed.ncbi.nlm.nih.gov/19859983/</ref> Zinc Ionophores kill cancer cells via ways such as proteasome inhibition and lysosomal disruption, and thus, have proven to be potential anticancer agents.<ref>https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.253</ref>
== Antiviral Activity ==
Zinc Ionophores, Hinokitiol, and Pyrithione are useful in the inhibition of Picornavirus replication through the interference with the viral polyprotein proper processing.<ref>https://pubmed.ncbi.nlm.nih.gov/18922875/</ref> Hinokitiol and Pyrithione also result in a swift importation of extracellular Zn2+ ions into the cells, which increases the inhibition against Picornavirus infection.<ref>https://jvi.asm.org/content/83/1/58</ref>
== Anticancer Activity ==
The ability to bind on Zinc ions allows Zinc ionophores to cause apoptosis within cancer cells.<ref>https://pubmed.ncbi.nlm.nih.gov/19859983/</ref> Zinc Ionophores kill cancer cells via ways such as proteasome inhibition and lysosomal disruption, and thus, have proven to be potential anticancer agents.<ref>https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.253</ref>