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Alkaline hydrolysis is the cleavage of [[covalent]] chemical bonds by a high [[pH]].
'''Alkaline hydrolysis''' is the cleavage of [[covalent]] chemical bonds by a high [[pH]].
At high pH, [[RNA]] molecules have 2' hydroxyls that attack the 3' phosphodiester bond and degrade the RNA polymer to monoribonucleotides.
At high pH, [[RNA]] molecules have 2' hydroxyls that attack the 3' phosphodiester bond and degrade the RNA polymer to monoribonucleotides.