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:Conclusions: in a cohort of 166 patients from 18 to 85 years hospitalised with COVID-19, hydroxychloroquine treatment with 800mg added loading dose increased survival when patients were admitted in early stages of the disease. '''''There was a non-statistically significant trend towards survival in all groups, which will have to be clarified in subsequent studies.'''''
 
:Conclusions: in a cohort of 166 patients from 18 to 85 years hospitalised with COVID-19, hydroxychloroquine treatment with 800mg added loading dose increased survival when patients were admitted in early stages of the disease. '''''There was a non-statistically significant trend towards survival in all groups, which will have to be clarified in subsequent studies.'''''
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== Mechanism ==
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HCQ inhibits the [[cytokine storm]].  Professor Raoult of [[France]] has suggested additional ways that HCQ helps block [[COVID-19]] replication:
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1) HCQ inhibits the attachment of the amino acid region 111-158 of the viral spike of [[COVID-19]] to gangliosides
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2) The [[COVID-19]] replicative cycle that could be inhibited by HCQ is the pH-dependent viral endocytosis.
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3)  Transcription could be impeded by HCQ.
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4)  HCQ may block the posttranslational modifications of viral proteins within the endoplasmic reticulum and trans-Golgi network vesicles, perhaps by impairing the maturation of its M protein [113].
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5)  HCQ could be helpful concerning cell-signaling, in particular through MAPK 
    
== CDC ==
 
== CDC ==
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