Difference between revisions of "Koch's postulates"

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===Epidemiological association===
 
===Epidemiological association===
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The suspected cause must be strongly associated with the disease.
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An association should exist between a microorganism and disease (i.e., the organism is identified or recovered from patients).
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The molecular version of this postulate states that an epidemiological association exists between presence of a trait and virulence, that a specific mutation be constructed to inhibit the function resulting in decrease
 
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in virulence, and finally that the mutation be complemented in trans with only the wild-type allele of the
 
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mutated gene provided on a recombinant plasmid.
 
  
 
===Isolation===
 
===Isolation===

Revision as of 21:08, January 8, 2009

Dna ncifcrf gov.jpg This article/section deals with advance bioscience concepts appropriate for a student in late university and graduate school.

Koch's postulates are a set of broad principles laid out by Robert Koch in the 1880's. They are the basic criteria for determining what is and is not an infectious disease in plants, animals, and humans. Because they are at the level of philosophy of science, they can be applied to viral, bacterial, or parasite-caused infection theories. Though aspects of the principles were not original, Robert Koch provided an experimental basis for these principles that was very convincing to the scientists of his day.

The Postulates

Epidemiological association

An association should exist between a microorganism and disease (i.e., the organism is identified or recovered from patients).

Isolation

The suspected pathogen can be isolated - and propagated - outside the host.

Transmission Pathogenesis

Transfer of the suspected pathogen to an uninfected host, man or animal, produces the disease in that host.